Age at Epstein-Barr virus infection and Epstein-Barr virus nuclear antigen-1 antibodies in Swedish children

There is strong evidence supporting a role for Epstein-Barr virus (EBV) in the etiopathogenesis of multiple sclerosis (MS). Because of the strong association between antibody (Ab) titer against EBV nuclear antigen 1 (EBNA1) and late age at EBV infection, manifested as infectious mononucleosis (IM), and MS risk, we sought to determine whether age at primary EBV infection was associated with subsequent anti-EBNA1 Ab titer in a longitudinal study of Swedish children with EBV seropositivity and anti-EBNA1 Ab titers measured at ages 2, 5, and 10.

Saghafian-Hedengren, ShanieStockholms universitet,Avdelningen för immunologi (author)
Sverremark-Ekström, EvaStockholms universitet,Avdelningen för immunologi(Swepub:su)esver (author)
Nilsson, CarolineKarolinska Institutet (author)
Ascherio, Alberto (author)
Stockholms universitetAvdelningen för immunologi (creator_code:org_t)

In:Multiple Sclerosis and Related Disorders: Elsevier BV1:3, s. 136-1382211-03482211-0356

By the author/editor: Simon, K. Claire; Saghafian-Hedeng ...; Sverremark-Ekstr ...; Nilsson, Carolin ...; Ascherio, Albert ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

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