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Gene delivery using...
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Abdelhamid, Hani NasserStockholms universitet,Institutionen för material- och miljökemi (MMK),Assiut University, Egypt
(author)
Gene delivery using cell penetrating peptides-zeolitic imidazolate frameworks
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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Elsevier BV,2020
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:su-181905
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-181905URI
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https://doi.org/10.1016/j.micromeso.2020.110173DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Cell-penetrating peptides (CPPs), and metal-organic frameworks (MOFs) are promising as next-generation for the delivery of gene-based therapeutic agents. Oligonucleotide (ON)-mediated assembly of nanostructures composed of hierarchical porous zeolitic imidazolate framework (ZIF-8), and nanoparticles such as graphene oxide (GO), and magnetic nanoparticles (MNPs) for gene therapy are reported. Five different types of non-viral vectors (ZIF-8, RhB@ZIF-8, BSA@ZIF-8, MNPs@ZIF-8, and GO@ZIF-8), and three gene therapeutic agents (plasmid, splice correction oligonucleotides (SCO), and small interfering RNA (siRNA)) were investigated. The polyplexes were characterized and applied for gene transfection. The materials show very low toxicity with high efficiency for luciferase transfection. ZIF-8 enhances the transfection of plasmid, SCO, siRNA of CPPs by 2-8 folds. The mechanism of the cell uptakes was also highlighted. Data reveal cell internalization via scavenger class A (SCARA).
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Dowaidar, MoatazStockholms universitet,Institutionen för biokemi och biofysik(Swepub:su)mdowa
(author)
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Hällbrink, MattiasStockholms universitet,Institutionen för biokemi och biofysik
(author)
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Langel, ÜloStockholms universitet,Institutionen för biokemi och biofysik(Swepub:su)ulo
(author)
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Stockholms universitetInstitutionen för material- och miljökemi (MMK)
(creator_code:org_t)
Related titles
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In:Microporous and Mesoporous Materials: Elsevier BV3001387-18111873-3093
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