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Balance between Tra...
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Papenberg, GoranKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
(author)
Balance between Transmitter Availability and Dopamine D2 Receptors in Prefrontal Cortex Influences Memory Functioning
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2019-09-02
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Oxford University Press (OUP),2020
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:su-182909
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-182909URI
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https://doi.org/10.1093/cercor/bhz142DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169317URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:143821924URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Insufficient or excessive dopaminergic tone impairs cognitive performance. We examine whether the balance between transmitter availability and dopamine (DA) D2 receptors (D2DRs) is important for successful memory performance in a large sample of adults (n= 175, 64-68 years). The Catechol-O-Methyltransferase polymorphism served as genetic proxy for endogenous prefrontal DA availability, and D2DRs in dorsolateral prefrontal cortex (dlPFC) were measured with [C-11]raclopride-PET. Individuals for whom D2DR status matched DA availability showed higher levels of episodic and working-memory performance than individuals with insufficient or excessive DA availability relative to the number of receptors. A similar pattern restricted to episodic memory was observed for D2DRs in caudate. Functional magnetic resonance imaging data acquired during working-memory performance confirmed the importance of a balanced DA system for load-dependent brain activity in dlPFC. Our data suggest that the inverted-U-shaped function relating DA signaling to cognition is modulated by a dynamic association between DA availability and receptor status.
Subject headings and genre
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Karalija, Nina,1984-Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)nine0001
(author)
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Salami, AlirezaKarolinska Institutet,Umeå universitet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Umeå University, Sweden,Umeå centrum för funktionell hjärnavbildning (UFBI),Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)(Swepub:umu)alsa0014
(author)
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Rieckmann, AnnaUmeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)anri0051
(author)
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Andersson, MicaelUmeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)mian0001
(author)
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Axelsson, Jan,1966-Umeå universitet,Radiofysik,Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)jaax0004
(author)
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Riklund, Katrine,MD, PhD, Professor,1963-Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)(Swepub:umu)kaah0001
(author)
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Lindenberger, Ulman
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Lövdén, MartinKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
(author)
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Nyberg, Lars,1966-Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för integrativ medicinsk biologi (IMB)(Swepub:umu)lany0001
(author)
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Bäckman, LarsKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
(author)
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Stockholms universitetCentrum för forskning om äldre och åldrande (ARC), (tills m KI)
(creator_code:org_t)
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In:Cerebral Cortex: Oxford University Press (OUP)30:3, s. 989-10001047-32111460-2199
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Papenberg, Goran
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Salami, Alireza
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Cerebral Cortex
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Stockholm University
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