Relationship between sleep characteristics and markers of inflammation in Swedish women from the general population

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Relationship between sleep characteristics and markers of inflammation in Swedish women from the general population

Ghilotti, Francesca (author)

Bellocco, Rino (author): Karolinska Institutet

Trolle Lagerros, Ylva (author): Karolinska Institutet

Thorson, Anna (author)

Theorell-Haglöw, Jenny (author): Uppsala universitet,Lung- allergi- och sömnforskning

Åkerstedt, Torbjörn (author): Stockholms universitet,Stressforskningsinstitutet,Karolinska Institutet, Sweden

Lindberg, Eva (author): Uppsala universitet,Lung- allergi- och sömnforskning,Lungmedicin och allergologi, Respiratory Medicine and Allergology

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(creator_code:org_t)

2020-05-22
2021
English.
In: Journal of Sleep Research. - : Wiley. - 0962-1105 .- 1365-2869. ; 30:2

Related links:: https://doi.org/10.1...; show more...; https://onlinelibrar...; https://uu.diva-port... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; https://urn.kb.se/re...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Systemic inflammation is thought to mediate the link between sleep and cardiovascular outcomes, but previous studies on sleep habits and inflammation markers have found inconsistent results. This study investigated the relationship between sleep characteristics and C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF alpha). A representative sample of 319 Swedish women was randomly selected from the general population for in-home polysomnography, sleep questionnaire and blood samples. As variables were highly correlated, principal component analysis was used to reduce the number of original variables. Linear regression with log-transformation of the outcomes (lnCRP, lnIL-6 and lnTNF alpha) and quantile regression were fitted to estimate cross-sectional relationships. Multivariable linear regression models suggested a significant association of insomnia symptoms (self-reported) with higher lnCRP levels (beta = 0.11; 95% confidence interval [CI] = 0.02; 0.21), but not with lnIL-6 and lnTNF alpha. From quantile regression analysis we found that a high non-restorative index (subjective) and insomnia symptoms (self-reported) were associated with higher values of CRP, especially in the highest quantiles of the CRP distribution (90th percentile: beta = 0.71; 95% CI = 0.17; 1.24. beta = 1.23; 95% CI = 0.44; 2.02, respectively). Additionally, higher amounts of rapid eye movement (REM) sleep were associated with lower CRP values (90th percentile: beta = -0.80; 95% CI = -0.14; -1.46). In conclusion, sleep disturbances (self-reported), specifically difficulties maintaining sleep and early morning awakenings, but not sleep duration (neither subjective nor objective), were associated with higher CRP levels. No association was found with IL-6 or TNF alpha. Elevated REM sleep was associated with lower CRP levels. The results suggest that inflammation might be an intermediate mechanism linking sleep and health in women.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
SOCIAL SCIENCES -- Psychology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)

Keyword

community-based
C-reactive protein
cross-sectional
polysomnography
sleep disturbance
women
Psychology
psykologi

Publication and Content Type

ref (subject category)
art (subject category)

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

SOCIAL SCIENCES: SOCIAL SCIENCES; and Psychology

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