Tri-modal imaging of gold-dotted magnetic nanoparticles for magnetic resonance imaging, computed tomography and intravascular ultrasound: an in vitro study

Tri-modal imaging of gold-dotted magnetic nanoparticles for magnetic resonance imaging, computed tomography and intravascular ultrasound : an in vitro study

Aim: To examine the multimodal contrasting ability of gold-dotted magnetic nanoparticles (Au*MNPs) for magnetic resonance (MR), computed tomography (CT) and intravascular ultrasound (IVUS) imaging.Materials & methods: Au*MNPs were prepared by adapting an impregnation method, without using surface capping reagents and characterized (transmission electron microscopy, x-ray diffraction and Fourier-transform infrared spectroscopy) with theirin vitrocytotoxicity assessed, followed by imaging assessments.Results: The contrast-enhancing ability of Au*MNPs was shown to be concentration-dependent across MR, CT and IVUS imaging. The Au content of the Au*MNP led to evident increases of the IVUS signal.Conclusion: We demonstrated that Au*MNPs showed concentration-dependent contrast-enhancing ability in MRI and CT imaging, and for the first-time in IVUS imaging due to the Au content. These Au*MNPs are promising toward solidifying tri-modal imaging-based theragnostics.

Papanastasiou, Giorgos (author)
Tai, Cheuk-WaiStockholms universitet,Institutionen för material- och miljökemi (MMK)(Swepub:su)ctai (author)
Moran, Carmel M. (author)
Jansen, Maurits A. (author)
Tavares, Adriana A. S. (author)
Lennen, Ross J. (author)
Corral, Carlos Alcaide (author)
Wang, Chengjia (author)
Thomson, Adrian J. W. (author)
Berry, Catherine C. (author)
Yiu, Humphrey H. P. (author)
Stockholms universitetInstitutionen för material- och miljökemi (MMK) (creator_code:org_t)

By the author/editor: Kuhn, Joel; Papanastasiou, G ...; Tai, Cheuk-Wai; Moran, Carmel M.; Jansen, Maurits ...; Tavares, Adriana ...; show more...; Lennen, Ross J.; Corral, Carlos A ...; Wang, Chengjia; Thomson, Adrian ...; Berry, Catherine ...; Yiu, Humphrey H. ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Radiology Nuclea ...

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