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Tri-modal imaging o...
Tri-modal imaging of gold-dotted magnetic nanoparticles for magnetic resonance imaging, computed tomography and intravascular ultrasound : an in vitro study
- Article/chapterEnglish2020
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Future Medicine Ltd,2020
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LIBRIS-ID:oai:DiVA.org:su-186412
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-186412URI
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https://doi.org/10.2217/nnm-2020-0236DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Aim: To examine the multimodal contrasting ability of gold-dotted magnetic nanoparticles (Au*MNPs) for magnetic resonance (MR), computed tomography (CT) and intravascular ultrasound (IVUS) imaging.Materials & methods: Au*MNPs were prepared by adapting an impregnation method, without using surface capping reagents and characterized (transmission electron microscopy, x-ray diffraction and Fourier-transform infrared spectroscopy) with theirin vitrocytotoxicity assessed, followed by imaging assessments.Results: The contrast-enhancing ability of Au*MNPs was shown to be concentration-dependent across MR, CT and IVUS imaging. The Au content of the Au*MNP led to evident increases of the IVUS signal.Conclusion: We demonstrated that Au*MNPs showed concentration-dependent contrast-enhancing ability in MRI and CT imaging, and for the first-time in IVUS imaging due to the Au content. These Au*MNPs are promising toward solidifying tri-modal imaging-based theragnostics.
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Papanastasiou, Giorgos
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Tai, Cheuk-WaiStockholms universitet,Institutionen för material- och miljökemi (MMK)(Swepub:su)ctai
(author)
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Moran, Carmel M.
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Jansen, Maurits A.
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Tavares, Adriana A. S.
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Lennen, Ross J.
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Corral, Carlos Alcaide
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Wang, Chengjia
(author)
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Thomson, Adrian J. W.
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Berry, Catherine C.
(author)
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Yiu, Humphrey H. P.
(author)
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Stockholms universitetInstitutionen för material- och miljökemi (MMK)
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In:Nanomedicine: Future Medicine Ltd15:251743-58891748-6963
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Kuhn, Joel
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Papanastasiou, G ...
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Tai, Cheuk-Wai
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Moran, Carmel M.
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Jansen, Maurits ...
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Lennen, Ross J.
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Corral, Carlos A ...
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Wang, Chengjia
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
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Nanomedicine
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Stockholm University