Search: onr:"swepub:oai:DiVA.org:su-188138" > A healthy lifestyle...
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000 | 05180naa a2200493 4500 | |
001 | oai:DiVA.org:su-188138 | |
003 | SwePub | |
008 | 210104s2021 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:145134302 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1881382 URI |
024 | 7 | a https://doi.org/10.1007/s00125-020-05324-z2 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1451343022 URI |
040 | a (SwePub)sud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Yang, Rongrong4 aut |
245 | 1 0 | a A healthy lifestyle mitigates the risk of heart disease related to type 2 diabetes :b a prospective nested case-control study in a nationwide Swedish twin cohort |
264 | c 2020-11-10 | |
264 | 1 | b Springer Science and Business Media LLC,c 2021 |
338 | a print2 rdacarrier | |
520 | a Aims/hypothesis We aimed to examine the association between type 2 diabetes and major subtypes of heart disease, to assess the role of genetic and early-life familial environmental factors in this association and to explore whether and to what extent a healthy lifestyle mitigates the risk of heart disease related to type 2 diabetes.Methods In this prospective nested case-control study based on the Swedish Twin Registry, 41,463 twin individuals who were aged >= 40 and heart disease-free were followed up for 16 years (from 1998 to 2014) to detect incident heart disease. Type 2 diabetes was ascertained from self-report, the National Patient Registry and glucose-lowering medication use. Heart disease diagnosis (including coronary heart disease, cardiac arrhythmias and heart failure) and onset age were identified from the National Patient Registry. Healthy lifestyle-related factors consisted of being a non-smoker, no/mild alcohol consumption, regular physical activity and being non-overweight. Participants were divided into three groups according to the number of lifestyle-related factors: (1) unfavourable (participants who had no or only one healthy lifestyle factor); (2) intermediate (any two or three); and (3) favourable (four). Generalised estimating equation models for unmatched case-control design and conditional logistic regression for co-twin control design were used in data analyses.Results Of all participants, 2304 (5.5%) had type 2 diabetes at baseline. During the observation period, 9262 (22.3%) had any incident heart disease. In unmatched case-control analyses and co-twin control analyses, the multi-adjusted OR and 95% CI of heart disease related to type 2 diabetes was 4.36 (3.95, 4.81) and 4.89 (3.88, 6.16), respectively. The difference in ORs from unmatched case-control analyses vs co-twin control analyses was statistically significant (OR 1.57; 95% CI 1.42, 1.73; p < 0.001). In stratified analyses by type 2 diabetes, compared with an unfavourable lifestyle, an intermediate lifestyle or a favourable lifestyle was associated with a significant 32% (OR 0.68; 95% CI 0.49, 0.93) or 56% (OR 0.44; 95% CI 0.30, 0.63) decrease in heart disease risk among patients with type 2 diabetes, respectively. There were significant additive and multiplicative interactions between lifestyle and type 2 diabetes on heart disease.Conclusions/interpretation Type 2 diabetes is associated with more than fourfold increased risk of heart disease. The association still remains statistically significant, even after fully controlling for genetic and early-life familial environmental factors. However, greater adherence to a healthy lifestyle may significantly mitigate the risk of heart disease related to type 2 diabetes. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
653 | a Heart disease | |
653 | a Lifestyle | |
653 | a Prospective nested case-control study in twins | |
653 | a The Swedish Twin Registry | |
653 | a Type 2 diabetes | |
700 | 1 | a Xu, Hui4 aut |
700 | 1 | a Pedersen, Nancy L.u Karolinska Institutet4 aut |
700 | 1 | a Li, Xuerui4 aut |
700 | 1 | a Yu, Jing4 aut |
700 | 1 | a Bao, Cuiping4 aut |
700 | 1 | a Qi, Xiuying4 aut |
700 | 1 | a Xu, Weiliu Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Tianjin Medical University, China4 aut |
710 | 2 | a Karolinska Institutetb Centrum för forskning om äldre och åldrande (ARC), (tills m KI)4 org |
773 | 0 | t Diabetologiad : Springer Science and Business Media LLCg 64, s. 530-539q 64<530-539x 0012-186Xx 1432-0428 |
856 | 4 | u https://doi.org/10.1007/s00125-020-05324-zy Fulltext |
856 | 4 | u https://link.springer.com/content/pdf/10.1007/s00125-020-05324-z.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-188138 |
856 | 4 8 | u https://doi.org/10.1007/s00125-020-05324-z |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:145134302 |
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