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Battleground midgut : The cost to the mosquito for hosting the malaria parasite
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- Hajkazemian, Melika (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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- Bossé, Clément (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,François Rabelais University, France
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- Mozūraitis, Raimondas (author)
- Stockholms universitet,Zoologiska institutionen,Nature Research Centre, Lithuania
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- (creator_code:org_t)
- 2020-11-23
- 2021
- English.
- In: Biology of the Cell. - : Wiley. - 0248-4900 .- 1768-322X. ; 113:2, s. 79-94
- Research review (peer-reviewed)
Abstract
Subject headings
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- In eco-evolutionary studies of parasite-host interactions, virulence is defined as a reduction in host fitness as a result of infection relative to an uninfected host. Pathogen virulence may either promote parasite transmission, when correlated with higher parasite replication rate, or decrease the transmission rate if the pathogen quickly kills the host. This evolutionary mechanism, referred to as 'trade-off' theory, proposes that pathogen virulence evolves towards a level that most benefits the transmission. It has been generally predicted that pathogens evolve towards low virulence in their insect vectors, mainly due to the high dependence of parasite transmission on their vector survival. Therefore, the degree of virulence which malaria parasites impose on mosquito vectors may depend on several external and internal factors. Here, we review briefly (i) the role of mosquito in parasite development, with a particular focus on mosquito midgut as the battleground between Plasmodium and the mosquito host. We aim to point out (ii) the histology of the mosquito midgut epithelium and its role in host defence against parasite's countermeasures in the three main battle sites, namely (a) the lumen (microbiota and biochemical environment), (b) the peritrophic membrane (physical barrier) and (c) the tubular epithelium including the basal membrane (physical and biochemical barrier). Lastly, (iii) we describe the impact which malaria parasite and its virulence factors have on mosquito fitness.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- Histology
- Host
- Mosquito
- Parasite
- Transmission
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