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Common diseases alt...
Common diseases alter the physiological age-related blood microRNA profile
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Fehlmann, Tobias (author)
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Lehallier, Benoit (author)
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Schaum, Nicholas (author)
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Hahn, Oliver (author)
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Kahraman, Mustafa (author)
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Li, Yongping (author)
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Grammes, Nadja (author)
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Geffers, Lars (author)
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Backes, Christina (author)
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Balling, Rudi (author)
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Kern, Fabian (author)
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Krüger, Rejko (author)
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Lammert, Frank (author)
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Ludwig, Nicole (author)
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Meder, Benjamin (author)
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- Fromm, Bastian (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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Maetzler, Walter (author)
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Berg, Daniela (author)
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Brockmann, Kathrin (author)
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Deuschle, Christian (author)
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von Thaler, Anna-Katharina (author)
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Eschweiler, Gerhard W. (author)
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Milman, Sofiya (author)
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Barziliai, Nir (author)
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Reichert, Matthias (author)
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Wyss-Coray, Tony (author)
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Meese, Eckart (author)
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Keller, Andreas (author)
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(creator_code:org_t)
- 2020-11-24
- 2020
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1
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https://doi.org/10.1...
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https://www.nature.c...
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Abstract
Subject headings
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- Aging is a key risk factor for chronic diseases of the elderly. MicroRNAs regulate post-transcriptional gene silencing through base-pair binding on their target mRNAs. We identified nonlinear changes in age-related microRNAs by analyzing whole blood from 1334 healthy individuals. We observed a larger influence of the age as compared to the sex and provide evidence for a shift to the 5’ mature form of miRNAs in healthy aging. The addition of 3059 diseased patients uncovered pan-disease and disease-specific alterations in aging profiles. Disease biomarker sets for all diseases were different between young and old patients. Computational deconvolution of whole-blood miRNAs into blood cell types suggests that cell intrinsic gene expression changes may impart greater significance than cell abundance changes to the whole blood miRNA profile. Altogether, these data provide a foundation for understanding the relationship between healthy aging and disease, and for the development of age-specific disease biomarkers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Fehlmann, Tobias
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Lehallier, Benoi ...
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Schaum, Nicholas
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Hahn, Oliver
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Kahraman, Mustaf ...
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Li, Yongping
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show more...
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Grammes, Nadja
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Geffers, Lars
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Backes, Christin ...
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Balling, Rudi
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Kern, Fabian
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Krüger, Rejko
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Lammert, Frank
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Ludwig, Nicole
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Meder, Benjamin
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Fromm, Bastian
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Maetzler, Walter
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Berg, Daniela
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Brockmann, Kathr ...
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Deuschle, Christ ...
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von Thaler, Anna ...
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Eschweiler, Gerh ...
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Milman, Sofiya
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Barziliai, Nir
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Reichert, Matthi ...
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Wyss-Coray, Tony
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Meese, Eckart
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Keller, Andreas
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Nature Communica ...
- By the university
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Stockholm University