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Circulating miRNA S...
Circulating miRNA Spaceflight Signature Reveals Targets for Countermeasure Development
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Malkani, Sherina (author)
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Chin, Christopher R. (author)
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Cekanaviciute, Egle (author)
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Mortreux, Marie (author)
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Okinula, Hazeem (author)
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- Tarbier, Marcel (author)
- Stockholms universitet,Science for Life Laboratory (SciLifeLab),Institutionen för molekylär biovetenskap, Wenner-Grens institut
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Schreurs, Ann-Sofie (author)
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Shirazi-Fard, Yasaman (author)
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Tahimic, Candice G. T. (author)
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Rodriguez, Deyra N. (author)
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Sexton, Brittany S. (author)
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Butler, Daniel (author)
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Verma, Akanksha (author)
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Bezdan, Daniela (author)
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Durmaz, Ceyda (author)
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MacKay, Matthew (author)
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Melnick, Ari (author)
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Meydan, Cem (author)
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Li, Sheng (author)
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Garrett-Bakelman, Francine (author)
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- Fromm, Bastian (author)
- Stockholms universitet,Science for Life Laboratory (SciLifeLab),Institutionen för molekylär biovetenskap, Wenner-Grens institut
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Afshinnekoo, Ebrahim (author)
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Langhorst, Brad W. (author)
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Dimalanta, Eileen T. (author)
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Cheng-Campbell, Margareth (author)
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Blaber, Elizabeth (author)
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Schisler, Jonathan C. (author)
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Vanderburg, Charles (author)
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- Friedländer, Marc R. (author)
- Stockholms universitet,Science for Life Laboratory (SciLifeLab),Institutionen för molekylär biovetenskap, Wenner-Grens institut
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McDonald, J. Tyson (author)
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Costes, Sylvain (author)
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Rutkove, Seward (author)
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Grabham, Peter (author)
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Mason, Christopher E. (author)
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Beheshti, Afshin (author)
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English.
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In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 33:10
- Related links:
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https://doi.org/10.1...
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- We have identified and validated a spaceflight-associated microRNA (miRNA) signature that is shared by rodents and humans in response to simulated, short-duration and long-duration spaceflight. Previous studies have identified miRNAs that regulate rodent responses to spaceflight in low-Earth orbit, and we have confirmed the expression of these proposed spaceflight-associated miRNAs in rodents reacting to simulated spaceflight conditions. Moreover, astronaut samples from the NASA Twins Study confirmed these expression signatures in miRNA sequencing, single-cell RNA sequencing (scRNA-seq), and single-cell assay for transposase accessible chromatin (scATAC-seq) data. Additionally, a subset of these miRNAs (miR-125, miR-16, and let-7a) was found to regulate vascular damage caused by simulated deep space radiation. To demonstrate the physiological relevance of key spaceflight-associated miRNAs, we utilized antagomirs to inhibit their expression and successfully rescue simulated deep-space-radiation-mediated damage in human 3D vascular constructs.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Malkani, Sherina
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Chin, Christophe ...
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Cekanaviciute, E ...
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Mortreux, Marie
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Okinula, Hazeem
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Tarbier, Marcel
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show more...
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Schreurs, Ann-So ...
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Shirazi-Fard, Ya ...
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Tahimic, Candice ...
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Rodriguez, Deyra ...
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Sexton, Brittany ...
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Butler, Daniel
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Verma, Akanksha
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Bezdan, Daniela
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Durmaz, Ceyda
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MacKay, Matthew
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Melnick, Ari
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Meydan, Cem
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Li, Sheng
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Garrett-Bakelman ...
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Fromm, Bastian
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Afshinnekoo, Ebr ...
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Langhorst, Brad ...
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Dimalanta, Eilee ...
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Cheng-Campbell, ...
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Blaber, Elizabet ...
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Schisler, Jonath ...
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Vanderburg, Char ...
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Friedländer, Mar ...
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McDonald, J. Tys ...
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Costes, Sylvain
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Rutkove, Seward
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Grabham, Peter
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Mason, Christoph ...
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Beheshti, Afshin
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
- Articles in the publication
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Cell Reports
- By the university
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Stockholm University