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Cellular Traffickin...
Cellular Trafficking of Glutathione Transferase M2-2 Between U373MG and SHSY-S7 Cells is Mediated by Exosomes
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-02-08
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Springer Science and Business Media LLC,2021
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:su-192592
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-192592URI
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https://doi.org/10.1007/s12640-020-00327-5DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:145894332URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The enzyme glutathione transferase M2-2, expressed in human astrocytes, increases its expression in the presence of aminochrome and catalyzes the conjugation of aminochrome, preventing its toxic effects. Secretion of the enzyme glutathione transferase M2-2 from U373MG cells, used as a cellular model for astrocytes, has been reported, and the enzyme is taken up by neuroblastoma SYSH-S7 cells and provide protection against aminochrome. The present study provides evidence that glutathione transferase M2-2 is released in exosomes from U373MG cells, thereby providing a means for intercellular transport of the enzyme. With particular relevance to Parkinson disease and other degenerative conditions, we propose a new mechanism by which astrocytes may protect dopaminergic neurons against the endogenous neurotoxin aminochrome.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Armijo, Alicia
(author)
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Muñoz, Patricia
(author)
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Hultenby, KjellKarolinska Institutet
(author)
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Hagg, Andres
(author)
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Inzunza, JoseKarolinska Institutet
(author)
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Nalvarte, IvanKarolinska Institutet
(author)
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Varshney, MukeshKarolinska Institutet
(author)
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Mannervik, BengtStockholms universitet,Institutionen för biokemi och biofysik(Swepub:su)bmann
(author)
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Segura-Aguilar, Juan
(author)
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Karolinska InstitutetInstitutionen för biokemi och biofysik
(creator_code:org_t)
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In:Neurotoxicity research: Springer Science and Business Media LLC39:2, s. 182-1901029-84281476-3524
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- By the author/editor
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Valdes, Raúl
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Armijo, Alicia
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Muñoz, Patricia
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Hultenby, Kjell
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Hagg, Andres
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Inzunza, Jose
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Nalvarte, Ivan
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Varshney, Mukesh
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Mannervik, Bengt
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Segura-Aguilar, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Neurotoxicity re ...
- By the university
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Stockholm University
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Karolinska Institutet