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  • Valdes, Raúl (author)

Cellular Trafficking of Glutathione Transferase M2-2 Between U373MG and SHSY-S7 Cells is Mediated by Exosomes

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-02-08
  • Springer Science and Business Media LLC,2021
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:su-192592
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-192592URI
  • https://doi.org/10.1007/s12640-020-00327-5DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:145894332URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The enzyme glutathione transferase M2-2, expressed in human astrocytes, increases its expression in the presence of aminochrome and catalyzes the conjugation of aminochrome, preventing its toxic effects. Secretion of the enzyme glutathione transferase M2-2 from U373MG cells, used as a cellular model for astrocytes, has been reported, and the enzyme is taken up by neuroblastoma SYSH-S7 cells and provide protection against aminochrome. The present study provides evidence that glutathione transferase M2-2 is released in exosomes from U373MG cells, thereby providing a means for intercellular transport of the enzyme. With particular relevance to Parkinson disease and other degenerative conditions, we propose a new mechanism by which astrocytes may protect dopaminergic neurons against the endogenous neurotoxin aminochrome.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Armijo, Alicia (author)
  • Muñoz, Patricia (author)
  • Hultenby, KjellKarolinska Institutet (author)
  • Hagg, Andres (author)
  • Inzunza, JoseKarolinska Institutet (author)
  • Nalvarte, IvanKarolinska Institutet (author)
  • Varshney, MukeshKarolinska Institutet (author)
  • Mannervik, BengtStockholms universitet,Institutionen för biokemi och biofysik(Swepub:su)bmann (author)
  • Segura-Aguilar, Juan (author)
  • Karolinska InstitutetInstitutionen för biokemi och biofysik (creator_code:org_t)

Related titles

  • In:Neurotoxicity research: Springer Science and Business Media LLC39:2, s. 182-1901029-84281476-3524

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