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Small noncoding RNA...
Small noncoding RNA profiling across cellular and biofluid compartments and their implications for multiple sclerosis immunopathology
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Zheleznyakova, Galina Yurevna (author)
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- Piket, Eliane (author)
- Karolinska Institutet
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- Needhamsen, Maria (author)
- Karolinska Institutet
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- Hagemann-Jensen, Michael (author)
- Karolinska Institutet
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- Ekman, Diana (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab)
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- Han, Yanan (author)
- Karolinska Institutet
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- James, Tojo (author)
- Karolinska Institutet
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- Khademi, Mohsen (author)
- Karolinska Institutet
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- Al Nimer, Faiez (author)
- Karolinska Institutet
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Scicluna, Patrick (author)
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Huang, Jesse (author)
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- Kockum, Ingrid (author)
- Karolinska Institutet
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- Faridani, Omid R. (author)
- Karolinska Institutet
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- Olsson, Tomas (author)
- Karolinska Institutet
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- Piehl, Fredrik (author)
- Karolinska Institutet
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- Jagodic, Maja (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2021-04-20
- 2021
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 118:17
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https://doi.org/10.1...
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https://www.pnas.org...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease affecting the central nervous system (CNS). Small non-coding RNAs (sncRNAs) and, in particular, microRNAs (miRNAs) have frequently been associated with MS. Here, we performed a comprehensive analysis of all classes of sncRNAs in matching samples of peripheral blood mononuclear cells (PBMCs), plasma, cerebrospinal fluid (CSF) cells, and cell-free CSF from relapsing-remitting (RRMS, n = 12 in relapse and n = 11 in remission) patients, secondary progressive (SPMS, n = 6) MS patients, and noninflammatory and inflammatory neurological disease controls (NINDC, n = 11; INDC, n = 5). We show widespread changes in miRNAs and sncRNA-derived fragments of small nuclear, nucleolar, and transfer RNAs. In CSF cells, 133 out of 133 and 115 out of 117 differentially expressed sncRNAs were increased in RRMS relapse compared to remission and RRMS compared to NINDC, respectively. In contrast, 65 out of 67 differentially expressed PBMC sncRNAs were decreased in RRMS compared to NINDC. The striking contrast between the periphery and CNS suggests that sncRNA-mediated mechanisms, including alternative splicing, RNA degradation, and mRNA translation, regulate the transcriptome of pathogenic cells primarily in the CNS target organ.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- multiple sclerosis
- microRNAs
- small noncoding RNAs
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Zheleznyakova, G ...
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Piket, Eliane
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Needhamsen, Mari ...
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Hagemann-Jensen, ...
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Ekman, Diana
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Han, Yanan
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show more...
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James, Tojo
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Khademi, Mohsen
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Al Nimer, Faiez
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Scicluna, Patric ...
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Huang, Jesse
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Kockum, Ingrid
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Faridani, Omid R ...
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Olsson, Tomas
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Piehl, Fredrik
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Jagodic, Maja
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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Proceedings of t ...
- By the university
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Stockholm University
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Karolinska Institutet