Search: onr:"swepub:oai:DiVA.org:su-194271" >
The glucose-depende...
The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling
-
Zhang, Qian (author)
-
Delessa, Challa Tenagne (author)
-
Augustin, Robert (author)
-
show more...
-
Bakhti, Mostafa (author)
-
Colldén, Gustav (author)
-
Drucker, Daniel J. (author)
-
Feuchtinger, Annette (author)
-
Garcia Caceres, Cristina (author)
-
Grandl, Gerald (author)
-
Harger, Alexandra (author)
-
Herzig, Stephan (author)
-
Hofmann, Susanna (author)
-
Holleman, Cassie Lynn (author)
-
- Jastroch, Martin (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
-
- Keipert, Susanne (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
-
Kleinert, Maximilian (author)
-
Knerr, Patrick J. (author)
-
Kulaj, Konxhe (author)
-
Legutko, Beata (author)
-
Lickert, Heiko (author)
-
Liu, Xue (author)
-
Luippold, Gerd (author)
-
Lutter, Dominik (author)
-
Malogajski, Emilija (author)
-
Tarquis Medina, Marta (author)
-
Mowery, Stephanie A. (author)
-
Blutke, Andreas (author)
-
Perez-Tilve, Diego (author)
-
Salinno, Ciro (author)
-
Sehrer, Laura (author)
-
DiMarchi, Richard D. (author)
-
Tschöp, Matthias H. (author)
-
Stemmer, Kerstin (author)
-
Finan, Brian (author)
-
Wolfrum, Christian (author)
-
Müller, Timo D. (author)
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English.
-
In: Cell Metabolism. - : Elsevier BV. - 1550-4131 .- 1932-7420. ; 33:4, s. 833-844
- Related links:
-
https://doi.org/10.1...
-
show more...
-
http://www.cell.com/...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Uncertainty exists as to whether the glucose-dependent insulinotropic polypeptide receptor (GIPR) should be activated or inhibited for the treatment of obesity. Gipr was recently demonstrated in hypothalamic feeding centers, but the physiological relevance of CNS Gipr remains unknown. Here we show that HFD-fed CNS-Gipr KO mice and humanized (h)GIPR knockin mice with CNS-hGIPR deletion show decreased body weight and improved glucose metabolism. In DIO mice, acute central and peripheral administration of acyl-GIP increases cFos neuronal activity in hypothalamic feeding centers, and this coincides with decreased body weight and food intake and improved glucose handling. Chronic central and peripheral administration of acyl-GIP lowers body weight and food intake in wild-type mice, but shows blunted/absent efficacy in CNS-Gipr KO mice. Also, the superior metabolic effect of GLP-1/GIP co-agonism relative to GLP-1 is extinguished in CNS-Gipr KO mice. Our data hence establish a key role of CNS Gipr for control of energy metabolism.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Zhang, Qian
-
Delessa, Challa ...
-
Augustin, Robert
-
Bakhti, Mostafa
-
Colldén, Gustav
-
Drucker, Daniel ...
-
show more...
-
Feuchtinger, Ann ...
-
Garcia Caceres, ...
-
Grandl, Gerald
-
Harger, Alexandr ...
-
Herzig, Stephan
-
Hofmann, Susanna
-
Holleman, Cassie ...
-
Jastroch, Martin
-
Keipert, Susanne
-
Kleinert, Maximi ...
-
Knerr, Patrick J ...
-
Kulaj, Konxhe
-
Legutko, Beata
-
Lickert, Heiko
-
Liu, Xue
-
Luippold, Gerd
-
Lutter, Dominik
-
Malogajski, Emil ...
-
Tarquis Medina, ...
-
Mowery, Stephani ...
-
Blutke, Andreas
-
Perez-Tilve, Die ...
-
Salinno, Ciro
-
Sehrer, Laura
-
DiMarchi, Richar ...
-
Tschöp, Matthias ...
-
Stemmer, Kerstin
-
Finan, Brian
-
Wolfrum, Christi ...
-
Müller, Timo D.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
- Articles in the publication
-
Cell Metabolism
- By the university
-
Stockholm University