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  • Liu, Shuo (author)

Long-term exposure to low-level air pollution and incidence of asthma : the ELAPSE project

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2020-12-10
  • European Respiratory Society (ERS),2021
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:su-194978
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-194978URI
  • https://doi.org/10.1183/13993003.030992020DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:146810293URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: Long-term exposure to ambient air pollution has been linked to childhood-onset asthma, although evidence is still insufficient. Within the multicentre project Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE), we examined the associations of long-term exposures to particulate matter with a diameter <2.5 mu m (PM2.5), nitrogen dioxide (NO2) and black carbon (BC) with asthma incidence in adults.Methods: We pooled data from three cohorts in Denmark and Sweden with information on asthma hospital diagnoses. The average concentrations of air pollutants in 2010 were modelled by hybrid land-use regression models at participants' baseline residential addresses. Associations of air pollution exposures with asthma incidence were explored with Cox proportional hazard models, adjusting for potential confounders.Results: Of 98326 participants, 1965 developed asthma during a mean follow-up of 16.6 years. We observed associations in fully adjusted models with hazard ratios of 1.22 (95% CI 1.04-1.43) per 5 mu g.m(-3) for PM2.5, 1.17 (95% CI 1.10-1.25) per 10 mu g.m(-3) for NO2 and 1.15 (95% CI 1.08-1.23) per 0.5 x 10(-5) m(-1) for BC. Hazard ratios were larger in cohort subsets with exposure levels below the European Union and US limit values and possibly World Health Organization guidelines for PM2.5 and NO2. NO 2 and BC estimates remained unchanged in two-pollutant models with PM2.5, whereas PM2.5 estimates were attenuated to unity. The concentration-response curves showed no evidence of a threshold.Conclusions: Long-term exposure to air pollution, especially from fossil fuel combustion sources such as motorised traffic, was associated with adult-onset asthma, even at levels below the current limit values.

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  • Therming Jorgensen, Jeanette (author)
  • Ljungman, PetterKarolinska Institutet (author)
  • Pershagen, GoranKarolinska Institutet (author)
  • Bellander, TomKarolinska Institutet (author)
  • Leander, KarinKarolinska Institutet (author)
  • Magnusson, Patrik K. E.Karolinska Institutet (author)
  • Rizzuto, DeboraKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),The Stockholm Gerontology Research Center, Sweden (author)
  • Hvidtfeldt, Ulla A. (author)
  • Nielsen, Ole Raaschou (author)
  • Wolf, Kathrin (author)
  • Hoffmann, Barbara (author)
  • Brnekree, Bert (author)
  • Strak, Maciej (author)
  • Chen, Jie (author)
  • Mehta, Amar (author)
  • Atkinson, Richard W. (author)
  • Bauwelrick, Mariska (author)
  • Varraso, Raphaelle (author)
  • Boutron-Ruault, Marie-Christine (author)
  • Brandt, Jorgen (author)
  • Cesaroni, Giulia (author)
  • Forastiere, Francesco (author)
  • Fecht, Daniela (author)
  • Gulliver, John (author)
  • Hertel, Ole (author)
  • de Hoogh, Kees (author)
  • Janssen, Nicole A. H. (author)
  • Katsouyanni, Klea (author)
  • Ketzel, Matthias (author)
  • Klompmaker, Jochem O. (author)
  • Nagel, Gabriele (author)
  • Oftedal, Bente (author)
  • Peters, Annette (author)
  • Tjonneland, Anne (author)
  • Rodopoulou, Sophia P. (author)
  • Samoli, Evangelia (author)
  • Kristoffersen, Doris Tove (author)
  • Sigsgaard, Torben (author)
  • Stafoggia, Massimo (author)
  • Vienneau, Danielle (author)
  • Weinmayr, Gudrun (author)
  • Hoek, Gerard (author)
  • Jovanovic Andersen, Zorana (author)
  • Karolinska InstitutetCentrum för forskning om äldre och åldrande (ARC), (tills m KI) (creator_code:org_t)

Related titles

  • In:European Respiratory Journal: European Respiratory Society (ERS)57:60903-19361399-3003

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