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Recent Smell Loss I...
Recent Smell Loss Is the Best Predictor of COVID-19 Among Individuals With Recent Respiratory Symptoms
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Gerkin, Richard C. (author)
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Ohla, Kathrin (author)
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Veldhuizen, Maria G. (author)
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show more...
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Joseph, Paule (author)
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Kelly, Christine E. (author)
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Bakke, Alyssa J. (author)
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Steele, Kimberley E. (author)
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Farruggia, Michael C. (author)
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Pellegrino, Robert (author)
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Pepino, Marta Y. (author)
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Bouysset, Cedric (author)
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Soler, Graciela M. (author)
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Pereda-Loth, Veronica (author)
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Dibattista, Michele (author)
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Cooper, Keiland W. (author)
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Croijmans, Ilja (author)
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Di Pizio, Antonella (author)
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Ozdener, Mehmet Hakan (author)
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Fjaeldstad, Alexander W. (author)
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Lin, Cailu (author)
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Sandell, Mari A. (author)
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Singh, Preet B. (author)
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Brindha, V. Evelyn (author)
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Olsson, Shannon B. (author)
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Saraiva, Luis R. (author)
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Ahuja, Gaurav (author)
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Alwashahi, Mohammed K. (author)
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Bhutani, Surabhi (author)
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D'Errico, Anna (author)
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Fornazieri, Marco A. (author)
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Golebiowski, Jerome (author)
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Hwang, Liang Dar (author)
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Ozturk, Lina (author)
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Roura, Eugeni (author)
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Spinelli, Sara (author)
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Whitcroft, Katherine L. (author)
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Faraji, Farhoud (author)
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Fischmeister, Florian Ph S. (author)
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Heinbockel, Thomas (author)
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Hsieh, Julien W. (author)
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Huart, Caroline (author)
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Konstantinidis, Iordanis (author)
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Menini, Anna (author)
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Morini, Gabriella (author)
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- Olofsson, Jonas K., 1978- (author)
- Stockholms universitet,Psykologiska institutionen
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Philpott, Carl M. (author)
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Pierron, Denis (author)
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Shields, Vonnie D. C. (author)
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Voznessenskaya, Vera V. (author)
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Albayay, Javier (author)
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Altundag, Aytug (author)
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Bensafi, Moustafa (author)
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Bock, Maria Adelaida (author)
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Calcinoni, Orietta (author)
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- Fredborg, William (author)
- Stockholms universitet,Psykologiska institutionen
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Laudamiel, Christophe (author)
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Lim, Juyun (author)
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- Lundstrom, Johan N. (author)
- Karolinska Institutet
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Macchi, Alberto (author)
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Meyer, Pablo (author)
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Moein, Shima T. (author)
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Santamaria, Enrique (author)
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Sengupta, Debarka (author)
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Dominguez, Paloma Rohlfs (author)
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Yanik, Huseyin (author)
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Hummel, Thomas (author)
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Hayes, John E. (author)
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Reed, Danielle R. (author)
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Niv, Masha Y. (author)
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Munger, Steven D. (author)
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Parma, Valentina (author)
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(creator_code:org_t)
- 2020-12-25
- 2021
- English.
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In: Chemical Senses. - : Oxford University Press (OUP). - 0379-864X .- 1464-3553. ; 46
- Related links:
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https://doi.org/10.1...
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- In a preregistered, cross-sectional study, we investigated whether olfactory loss is a reliable predictor of COVID-19 using a crowdsourced questionnaire in 23 languages to assess symptoms in individuals self-reporting recent respiratory illness. We quantified changes in chemosensory abilities during the course of the respiratory illness using 0–100 visual analog scales (VAS) for participants reporting a positive (C19+; n = 4148) or negative (C19−; n = 546) COVID-19 laboratory test outcome. Logistic regression models identified univariate and multivariate predictors of COVID-19 status and post-COVID-19 olfactory recovery. Both C19+ and C19− groups exhibited smell loss, but it was significantly larger in C19+ participants (mean ± SD, C19+: −82.5 ± 27.2 points; C19−: −59.8 ± 37.7). Smell loss during illness was the best predictor of COVID-19 in both univariate and multivariate models (ROC AUC = 0.72). Additional variables provide negligible model improvement. VAS ratings of smell loss were more predictive than binary chemosensory yes/no-questions or other cardinal symptoms (e.g., fever). Olfactory recovery within 40 days of respiratory symptom onset was reported for ~50% of participants and was best predicted by time since respiratory symptom onset. We find that quantified smell loss is the best predictor of COVID-19 amongst those with symptoms of respiratory illness. To aid clinicians and contact tracers in identifying individuals with a high likelihood of having COVID-19, we propose a novel 0–10 scale to screen for recent olfactory loss, the ODoR-19. We find that numeric ratings ≤2 indicate high odds of symptomatic COVID-19 (4 < OR < 10). Once independently validated, this tool could be deployed when viral lab tests are impractical or unavailable.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- anosmia
- chemosensory
- coronavirus
- hyposmia
- olfactory
- prediction
- psykologi
- Psychology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Gerkin, Richard ...
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Ohla, Kathrin
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Veldhuizen, Mari ...
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Joseph, Paule
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Kelly, Christine ...
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Bakke, Alyssa J.
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show more...
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Steele, Kimberle ...
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Farruggia, Micha ...
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Pellegrino, Robe ...
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Pepino, Marta Y.
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Bouysset, Cedric
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Soler, Graciela ...
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Pereda-Loth, Ver ...
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Dibattista, Mich ...
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Cooper, Keiland ...
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Croijmans, Ilja
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Di Pizio, Antone ...
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Ozdener, Mehmet ...
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Fjaeldstad, Alex ...
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Lin, Cailu
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Sandell, Mari A.
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Singh, Preet B.
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Brindha, V. Evel ...
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Olsson, Shannon ...
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Saraiva, Luis R.
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Ahuja, Gaurav
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Alwashahi, Moham ...
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Bhutani, Surabhi
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D'Errico, Anna
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Fornazieri, Marc ...
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Golebiowski, Jer ...
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Hwang, Liang Dar
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Ozturk, Lina
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Roura, Eugeni
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Spinelli, Sara
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Whitcroft, Kathe ...
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Faraji, Farhoud
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Fischmeister, Fl ...
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Heinbockel, Thom ...
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Hsieh, Julien W.
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Huart, Caroline
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Konstantinidis, ...
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Menini, Anna
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Morini, Gabriell ...
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Olofsson, Jonas ...
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Philpott, Carl M ...
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Pierron, Denis
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Shields, Vonnie ...
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Voznessenskaya, ...
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Albayay, Javier
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Altundag, Aytug
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Bensafi, Moustaf ...
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Bock, Maria Adel ...
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Calcinoni, Oriet ...
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Fredborg, Willia ...
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Laudamiel, Chris ...
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Lim, Juyun
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Lundstrom, Johan ...
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Macchi, Alberto
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Meyer, Pablo
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Moein, Shima T.
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Santamaria, Enri ...
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Sengupta, Debark ...
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Dominguez, Palom ...
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Yanik, Huseyin
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Hummel, Thomas
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Hayes, John E.
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Reed, Danielle R ...
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Niv, Masha Y.
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Munger, Steven D ...
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Parma, Valentina
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Chemical Senses
- By the university
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Stockholm University
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Karolinska Institutet