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Lactobacillus reute...
Lactobacillus reuteri Colonisation of Extremely Preterm Infants in a Randomised Placebo-Controlled Trial
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- Spreckels, Johanne (author)
- Linköpings universitet,Medicinska fakulteten,Institutionen för biomedicinska och kliniska vetenskaper,Univ Med Ctr Groningen, Netherlands
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- Wejryd, Erik (author)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, Barn- och ungdomskliniken i Norrköping
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- Marchini, Giovanna (author)
- Karolinska Univ Hosp & Inst, Sweden
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- Jonsson, Baldvin (author)
- Karolinska Institutet,Karolinska Univ Hosp & Inst, Sweden
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- de Vries, Dylan H. (author)
- Univ Med Ctr Groningen, Netherlands
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- Jenmalm, Maria (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten
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- Landberg, Eva (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Region Östergötland, Klinisk kemi
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- Sverremark-Ekström, Eva (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Sweden
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- Generó, Magali Marti, 1983- (author)
- Linköpings universitet,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten
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- Abrahamsson, Thomas (author)
- Linköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus
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(creator_code:org_t)
- 2021-04-24
- 2021
- English.
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In: Microorganisms. - : MDPI AG. - 2076-2607. ; 9:5
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Lactobacillus reuteri DSM 17938 supplementation reduces morbidities in very low birth weight infants (<1500 g), while the effect on extremely low birth weight infants (ELBW, <1000 g) is still questioned. In a randomised placebo-controlled trial (ClinicalTrials.gov ID NCT01603368), head growth, but not feeding tolerance or morbidities, improved in L. reuteri-supplemented preterm ELBW infants. Here, we investigate colonisation with the probiotic strain in preterm ELBW infants who received L. reuteri DSM 17938 or a placebo from birth to postmenstrual week (PMW) 36. Quantitative PCR was used on 582 faecal DNA samples collected from 132 ELBW infants at one, two, three, and four weeks, at PMW 36, and at two years of age. Human milk oligosaccharides were measured in 31 milk samples at two weeks postpartum. At least 86% of the ELBW infants in the L. reuteri group were colonised with the probiotic strain during the neonatal period, despite low gestational age, high antibiotic pressure, and independent of infant feeding mode. Higher concentrations of lacto-N-tetraose, sialyl-lacto-N-neotetraose c, and 6 '-sialyllactose in mother's milk weakly correlated with lower L. reuteri abundance. Within the L. reuteri group, higher L. reuteri abundance weakly correlated with a shorter time to reach full enteral feeding. Female sex and L. reuteri colonisation improved head growth from birth to four weeks of age. In conclusion, L. reuteri DSM 17938 supplementation leads to successful colonisation in ELBW infants.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- antibiotic
- extremely low birth weight
- feeding intolerance
- human milk oligosaccharide
- Lactobacillus reuteri
- premature
- probiotic
- randomised controlled trial
Publication and Content Type
- ref (subject category)
- art (subject category)
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