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Lithium ions displa...
Lithium ions display weak interaction with amyloid-beta (Aβ) peptides and have minor effects on their aggregation
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- Berntsson, Elina (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Tallinn University of Technology, Estonia
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- Paul, Suman (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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- Vosough, Faraz (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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- Sholts, Sabrina B. (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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- Jarvet, Jüri (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,The National Institute of Chemical Physics and Biophysics, Estonia
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- Roos, Per M. (author)
- Karolinska Institutet
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- Barth, Andreas (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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- Gräslund, Astrid (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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- Wärmländer, Sebastian (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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(creator_code:org_t)
- 2021-04-28
- 2021
- English.
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In: Acta Biochimica Polonica. - : Polskie Towarzystwo Biochemiczne (Polish Biochemical Society). - 0001-527X .- 1734-154X. ; 68:2, s. 169-179
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Abstract
Subject headings
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- Alzheimer’s disease (AD) is an incurable disease and the main cause of age-related dementia worldwide, despite decades of research. Treatment of AD with lithium (Li) has shown promising results, but the underlying mechanism is unclear. The pathological hallmark of AD brains is deposition of amyloid plaques, consisting mainly of amyloid-β (Aβ) peptides aggregated into amyloid fibrils. The plaques contain also metal ions of e.g. Cu, Fe, and Zn, and such ions are known to interact with Aβ peptides and modulate their aggregation and toxicity. The interactions between Aβ peptides and Li+ions have however not been well investigated. Here, we use a range of biophysical techniques to characterize in vitro interactions between Aβ peptides and Li+ions. We show that Li+ions display weak and non-specific interactions with Aβ peptides, and have minor effects on Aβ aggregation. These results indicate that possible beneficial effects of Li on AD pathology are not likely caused by direct interactions between Aβ peptides and Li+ions.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- Alzheimer's disease
- protein aggregation
- metal-protein binding
- neurodegeneration
- pharmaceutics
Publication and Content Type
- ref (subject category)
- art (subject category)
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