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A roadmap for the H...
A roadmap for the Human Developmental Cell Atlas
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- Haniffa, Muzlifah (author)
- Newcastle Univ, Biosci Inst, Newcastle Upon Tyne, Tyne & Wear, England.;Wellcome Sanger Inst, Hinxton, England.;Newcastle Hosp NHS Fdn Trust, Dept Dermatol, Newcastle Upon Tyne, Tyne & Wear, England.;Newcastle Hosp NHS Fdn Trust, NIHR Newcastle Biomed Res Ctr, Newcastle Upon Tyne, Tyne & Wear, England.
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Taylor, Deanne (author)
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- Linnarsson, Sten (author)
- Karolinska Institutet
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show more...
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Aronow, Bruce J. (author)
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Bader, Gary D. (author)
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Barker, Roger A. (author)
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Camara, Pablo G. (author)
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Camp, J. Gray (author)
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Chedotal, Alain (author)
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Copp, Andrew (author)
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Etchevers, Heather C. (author)
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Giacobini, Paolo (author)
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Gottgens, Berthold (author)
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Guo, Guoji (author)
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Hupalowska, Ania (author)
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James, Kylie R. (author)
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Kirby, Emily (author)
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Kriegstein, Arnold (author)
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- Lundeberg, Joakim (author)
- KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
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Marioni, John C. (author)
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Meyer, Kerstin B. (author)
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Niakan, Kathy K. (author)
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- Nilsson, Mats (author)
- Stockholms universitet,Science for Life Laboratory (SciLifeLab),Institutionen för biokemi och biofysik
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Olabi, Bayanne (author)
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Pe'er, Dana (author)
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Regev, Aviv (author)
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Rood, Jennifer (author)
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Rozenblatt-Rosen, Orit (author)
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Satija, Rahul (author)
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Teichmann, Sarah A. (author)
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Treutlein, Barbara (author)
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Vento-Tormo, Roser (author)
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- Webb, Simone (author)
- Newcastle Univ, Biosci Inst, Newcastle Upon Tyne, Tyne & Wear, England.
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Karolinska Institutet Newcastle Univ, Biosci Inst, Newcastle Upon Tyne, Tyne & Wear, England;Wellcome Sanger Inst, Hinxton, England.;Newcastle Hosp NHS Fdn Trust, Dept Dermatol, Newcastle Upon Tyne, Tyne & Wear, England.;Newcastle Hosp NHS Fdn Trust, NIHR Newcastle Biomed Res Ctr, Newcastle Upon Tyne, Tyne & Wear, England. (creator_code:org_t)
- 2021-09-08
- 2021
- English.
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 597:7875, s. 196-205
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Abstract
Subject headings
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- This Perspective outlines the Human Developmental Cell Atlas initiative, which uses state-of-the-art technologies to map and model human development across gestation, and discusses the early milestones that have been achieved. The Human Developmental Cell Atlas (HDCA) initiative, which is part of the Human Cell Atlas, aims to create a comprehensive reference map of cells during development. This will be critical to understanding normal organogenesis, the effect of mutations, environmental factors and infectious agents on human development, congenital and childhood disorders, and the cellular basis of ageing, cancer and regenerative medicine. Here we outline the HDCA initiative and the challenges of mapping and modelling human development using state-of-the-art technologies to create a reference atlas across gestation. Similar to the Human Genome Project, the HDCA will integrate the output from a growing community of scientists who are mapping human development into a unified atlas. We describe the early milestones that have been achieved and the use of human stem-cell-derived cultures, organoids and animal models to inform the HDCA, especially for prenatal tissues that are hard to acquire. Finally, we provide a roadmap towards a complete atlas of human development.
Subject headings
- NATURVETENSKAP -- Annan naturvetenskap (hsv//swe)
- NATURAL SCIENCES -- Other Natural Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Nature
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- By the author/editor
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Haniffa, Muzlifa ...
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Taylor, Deanne
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Linnarsson, Sten
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Aronow, Bruce J.
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Bader, Gary D.
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Barker, Roger A.
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show more...
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Camara, Pablo G.
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Camp, J. Gray
-
Chedotal, Alain
-
Copp, Andrew
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Etchevers, Heath ...
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Giacobini, Paolo
-
Gottgens, Bertho ...
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Guo, Guoji
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Hupalowska, Ania
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James, Kylie R.
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Kirby, Emily
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Kriegstein, Arno ...
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Lundeberg, Joaki ...
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Marioni, John C.
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Meyer, Kerstin B ...
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Niakan, Kathy K.
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Nilsson, Mats
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Olabi, Bayanne
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Pe'er, Dana
-
Regev, Aviv
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Rood, Jennifer
-
Rozenblatt-Rosen ...
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Satija, Rahul
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Teichmann, Sarah ...
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Treutlein, Barba ...
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Vento-Tormo, Ros ...
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Webb, Simone
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Other Natural Sc ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Nature
- By the university
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Stockholm University
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Royal Institute of Technology
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Karolinska Institutet