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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003517naa a2200529 4500
001oai:DiVA.org:su-198401
003SwePub
008211111s2021 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1984012 URI
0247 a https://doi.org/10.1093/molbev/msab0982 DOI
040 a (SwePub)su
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a for2 swepub-publicationtype
1001 a Linard, Benjamin4 aut
2451 0a Ten Years of Collaborative Progress in the Quest for Orthologs
264 c 2021-04-02
264 1b Oxford University Press (OUP),c 2021
338 a print2 rdacarrier
520 a Accurate determination of the evolutionary relationships between genes is a foundational challenge in biology. Homology-evolutionary relatedness-is in many cases readily determined based on sequence similarity analysis. By contrast, whether or not two genes directly descended from a common ancestor by a speciation event (orthologs) or duplication event (paralogs) is more challenging, yet provides critical information on the history of a gene. Since 2009, this task has been the focus of the Quest for Orthologs (QFO) Consortium. The sixth QFO meeting took place in Okazaki, Japan in conjunction with the 67th National Institute for Basic Biology conference. Here, we report recent advances, applications, and oncoming challenges that were discussed during the conference. Steady progress has been made toward standardization and scalability of new and existing tools. A feature of the conference was the presentation of a panel of accessible tools for phylogenetic profiling and several developments to bring orthology beyond the gene unit-from domains to networks. This meeting brought into light several challenges to come: leveraging orthology computations to get the most of the incoming avalanche of genomic data, integrating orthology from domain to biological network levels, building better gene models, and adapting orthology approaches to the broad evolutionary and genomic diversity recognized in different forms of life and viruses.
650 7a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng
653 a orthology
653 a viruses
653 a phylogenetic profiling
653 a paralogy
653 a xenology
653 a gene models
7001 a Ebersberger, Ingo4 aut
7001 a McGlynn, Shawn E.4 aut
7001 a Glover, Natasha4 aut
7001 a Mochizuki, Tomohiro4 aut
7001 a Patricio, Mateus4 aut
7001 a Lecompte, Odile4 aut
7001 a Nevers, Yannis4 aut
7001 a Thomas, Paul D.4 aut
7001 a Gabaldon, Toni4 aut
7001 a Sonnhammer, Eriku Stockholms universitet,Science for Life Laboratory (SciLifeLab),Institutionen för biokemi och biofysik4 aut0 (Swepub:su)esonn
7001 a Dessimoz, Christophe4 aut
7001 a Uchiyama, Ikuo4 aut
7102 a Stockholms universitetb Science for Life Laboratory (SciLifeLab)4 org
7730 t Molecular biology and evolutiond : Oxford University Press (OUP)g 38:8, s. 3033-3045q 38:8<3033-3045x 0737-4038x 1537-1719
8564 u https://doi.org/10.1093/molbev/msab098y Fulltext
8564 u https://academic.oup.com/mbe/article-pdf/38/8/3033/39457256/msab098.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-198401
8564 8u https://doi.org/10.1093/molbev/msab098

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