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Human inbreeding ha...
Human inbreeding has decreased in time through the Holocene
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Ceballos, Francisco C. (author)
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Gürün, Kanat (author)
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Altınışık, N. Ezgi (author)
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Gemici, Hasan Can (author)
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Karamurat, Cansu (author)
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Koptekin, Dilek (author)
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Vural, Kıvılcım Başak (author)
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Mapelli, Igor (author)
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Sağlıcan, Ekin (author)
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Sürer, Elif (author)
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Erdal, Yılmaz Selim (author)
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- Götherström, Anders (author)
- Stockholms universitet,Arkeologiska forskningslaboratoriet,Centre for Palaeogenetics, Sweden
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Özer, Füsun (author)
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Atakuman, Çiğdem (author)
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Somel, Mehmet (author)
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English.
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In: Current Biology. - : Elsevier BV. - 0960-9822 .- 1879-0445. ; 31:17, s. 3925-3934
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https://doi.org/10.1...
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http://www.cell.com/...
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Abstract
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- The history of human inbreeding is controversial.(1) In particular, how the development of sedentary and/or agricultural societies may have influenced overall inbreeding levels, relative to those of hunter-gatherer communities, is unclear.(2-5) Here, we present an approach for reliable estimation of runs of homozygosity (ROHs) in genomes with >= 3x mean sequence coverage across >1 million SNPs and apply this to 411 ancient Eurasian genomes from the last 15,000 years.(5-34) We show that the frequency of inbreeding, as measured by ROHs, has decreased over time. The strongest effect is associated with the Neolithic transition, but the trend has since continued, indicating a population size effect on inbreeding prevalence. We further show that most inbreeding in our historical sample can be attributed to small population size instead of consanguinity. Cases of high consanguinity were rare and only observed among members of farming societies in our sample. Despite the lack of evidence for common consanguinity in our ancient sample, consanguineous traditions are today prevalent in various modem-day Eurasian societies,(1, 35-37) suggesting that such practices may have become widespread within the last few millennia.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Ceballos, Franci ...
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Gürün, Kanat
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Altınışık, N. Ez ...
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Gemici, Hasan Ca ...
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Karamurat, Cansu
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Koptekin, Dilek
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show more...
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Vural, Kıvılcım ...
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Mapelli, Igor
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Sağlıcan, Ekin
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Sürer, Elif
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Erdal, Yılmaz Se ...
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Götherström, And ...
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Özer, Füsun
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Atakuman, Çiğdem
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Somel, Mehmet
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
- Articles in the publication
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Current Biology
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Stockholm University