Merging Directed C-H Activations with High-throughput Experimentation : Development of Predictable Iridium-catalyzed C-H Aminations Applicable to Late-stage Functionalizations

• Herein, we report an iridium-catalyzed directed C–H amination methodology developed using a high-throughput experimentation (HTE)-based strategy, applicable for the needs of automated modern drug discovery. The informer library approach for investigating the accessible directing group chemical space, in combination with functional group tolerance screening and substrate scope investigations, allowed for the generation of reaction application guidelines to aid future users. Applicability to late-stage functionalization of complex drugs and natural products, in combination with multiple deprotection protocols leading to the desirable aniline matched pairs, serve to demonstrate the utility of the method for drug discovery. Finally, reaction miniaturization to a nanomolar range highlights the opportunities for more sustainable screening with decreased material consumption. 

Subject headings

NATURVETENSKAP  -- Kemi -- Organisk kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Organic Chemistry (hsv//eng)

Keyword

catalysis

C−H activation

C−H amination

C−H functionalization

high-throughput experimentation

HTE

iridium

late-stage functionalization

LSF

Organic Chemistry

organisk kemi

Publication and Content Type

ref (subject category)

art (subject category)