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Engineered mesoporo...
Engineered mesoporous silica reduces long-term blood glucose and HbA1c, and improves metabolic parameters in prediabetics
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Baek, Jeanha (author)
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Robert-Nicoud, Ghislaine (author)
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Herrera Hidalgo, Carmen (author)
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Borg, Melissa L. (author)
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- Iqbal, Muhammad Naeem (author)
- Stockholms universitet,Institutionen för material- och miljökemi (MMK),Sigrid Therapeutics AB, Sweden
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Berlin, Roger (author)
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Lindgren, Maria (author)
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Waara, Erik (author)
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Uddén, Anna (author)
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Pietiläinen, Kirsi (author)
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- Bengtsson, Tore (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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(creator_code:org_t)
- Future Medicine Ltd, 2022
- 2022
- English.
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In: Nanomedicine. - : Future Medicine Ltd. - 1743-5889 .- 1748-6963. ; 17:1, s. 9-22
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https://doi.org/10.2...
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https://doi.org/10.2...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Aim: To investigate the effect of oral consumption of engineered mesoporous silica particles, SiPore15®, on long-term blood glucose levels and other metabolic parameters in individuals with prediabetes and newly diagnosed Type 2 diabetes. Method: An open-label, single-arm, multicenter trial was conducted in which SiPore15 was consumed three times daily for 12 weeks. Hemoglobin A1c (HbA1c, primary end point) and an array of metabolic parameters were measured at baseline and throughout the trial. Result: SiPore15 treatment significantly reduced HbA1c by a clinically meaningful degree and improved several disease-associated parameters with minimal side effects. Conclusion: The results from this study demonstrate the potential use of SiPore15 as a treatment for prediabetes that may also delay or prevent the onset of Type 2 diabetes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- diabetes prevention
- HbA1c
- medical device
- mesoporous silica particles
- prediabetes
- Type 2 diabetes
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Baek, Jeanha
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Robert-Nicoud, G ...
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Herrera Hidalgo, ...
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Borg, Melissa L.
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Iqbal, Muhammad ...
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Berlin, Roger
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show more...
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Lindgren, Maria
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Waara, Erik
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Uddén, Anna
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Pietiläinen, Kir ...
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Bengtsson, Tore
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Nanomedicine
- By the university
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Stockholm University