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SARS-CoV-2-specific...
SARS-CoV-2-specific B- and T-cell immunity in a population-based study of young Swedish adults
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- Björkander, Sophia (author)
- Karolinska Institutet
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- Du, Likun (author)
- Karolinska Institutet
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- Zuo, Fanglei (author)
- Karolinska Institutet
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- Ekström, Sandra (author)
- Karolinska Institutet
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- Wang, Yating (author)
- Karolinska Institutet
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- Wan, Hui (author)
- Karolinska Institutet
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Sherina, Natalia (author)
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Schoutens, Lisanne (author)
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- Andréll, Juni (author)
- Stockholms universitet,Science for Life Laboratory (SciLifeLab),Institutionen för biokemi och biofysik
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- Andersson, Niklas (author)
- Karolinska Institutet
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- Georgelis, Antonios (author)
- Karolinska Institutet
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- Bergström, Anna (author)
- Karolinska Institutet
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- Marcotte, Harold (author)
- Karolinska Institutet
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- Kull, Inger (author)
- Karolinska Institutet
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- Hammarström, Lennart (author)
- Karolinska Institutet
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- Melén, Erik (author)
- Karolinska Institutet
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- Pan-Hammarström, Qiang (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: Journal of Allergy and Clinical Immunology. - : Elsevier BV. - 0091-6749 .- 1097-6825. ; 149:1, s. 65-75
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Abstract
Subject headings
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- Background: Young adults are now considered major spreaders of coronavirus disease 2019 (COVID-19) disease. Although most young individuals experience mild to moderate disease, there are concerns of long-term adverse health effects. The impact of COVID-19 disease and to which extent population-level immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exists in young adults remain unclear.Objective: We conducted a population-based study on humoral and cellular immunity to SARS-CoV-2 and explored COVID-19 disease characteristics in young adults.Methods: We invited participants from the Swedish BAMSE (Barn [Children], Allergy Milieu, Stockholm, Epidemiology) birth cohort (age 24-27 years) to take part in a COVID-19 followup. From 980 participants (October 2020 to June 2021), we here present data on SARS-CoV-2 receptor-binding domain-specific IgM, IgA, and IgG titers measured by ELISA and on symptoms and epidemiologic factors associated with seropositivity. Further, SARS-CoV-2-specific memory B-and T-cell responses were detected for a subpopulation (n 5 108) by ELISpot and FluoroSpot.Results: A total of 28.4% of subjects were seropositive, of whom 18.4% were IgM single positive. One in 7 seropositive subjects was asymptomatic. Seropositivity was associated with use of public transport, but not with sex, asthma, rhinitis, IgE sensitization, smoking, or body mass index. In a subset of representative samples, 20.7% and 35.0% had detectable SARSCoV-2 specific B-and T-cell responses, respectively. B-and T-cell memory responses were clearly associated with seropositivity, but T-cell responses were also detected in 17.2% of seronegative subjects.Conclusions: Assessment of IgM and T-cell responses may improve population-based estimations of SARS-CoV-2 infection. The pronounced surge of both symptomatic and asymptomatic infections among young adults indicates that the large-scale vaccination campaign should be continued. (J Allergy Clin Immunol 2022;149:65-75.)
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- SARS-CoV-2
- COVID-19 disease
- IgM
- IgA
- IgG
- mem-ory T cells
- memory B cells
- young adults
- population-based cohort
- asthma
- risk factors
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Björkander, Soph ...
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Du, Likun
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Zuo, Fanglei
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Ekström, Sandra
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Wang, Yating
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Wan, Hui
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show more...
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Sherina, Natalia
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Schoutens, Lisan ...
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Andréll, Juni
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Andersson, Nikla ...
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Georgelis, Anton ...
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Bergström, Anna
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Marcotte, Harold
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Kull, Inger
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Hammarström, Len ...
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Melén, Erik
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Pan-Hammarström, ...
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show less...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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Journal of Aller ...
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Stockholm University
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Karolinska Institutet