Superior antioxidant and anti-ischemic neuroprotective effects of cerebrolysin in heat stroke following intoxication of engineered metal Ag and Cu nanoparticles: A comparative biochemical and physiological study with other stroke therapies

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Superior antioxidant and anti-ischemic neuroprotective effects of cerebrolysin in heat stroke following intoxication of engineered metal Ag and Cu nanoparticles : A comparative biochemical and physiological study with other stroke therapies

Sharma, Hari Shanker (author): Uppsala universitet,Anestesiologi och intensivvård

Muresanu, Dafin F. (author): Univ Med & Pharm, Dept Clin Neurosci, Cluj Napoca, Romania.;RoNeuro Inst Neurol Res & Diagnost, Cluj Napoca, Romania.

Ozkizilcik, Asya (author): Univ Arkansas, Dept Biomed Engn, Fayetteville, AR 72701 USA.

Sahib, Seaab (author): Univ Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA.

Tian, Z. Ryan (author): Univ Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA.

Vicente Lafuente, José (author): Univ Basque Country UPV EHU, Dept Neurosci, LaNCE, Leioa, Spain.

Castellani, Rudy J. (author): Univ Maryland, Dept Pathol, Baltimore, MD 21201 USA.

Nozari, Ala (author): Massachusetts Gen Hosp, Anesthesiol & Intens Care, Boston, MA 02114 USA.

Feng, Lianyuan (author): Bethune Int Peace Hosp, Dept Neurol, Shijiazhuang, Hebei, Peoples R China.

Buzoianu, Anca D. (author): Iuliu Hatieganu Univ Med & Pharm, Dept Clin Pharmacol & Toxicol, Cluj Napoca, Romania.

Menon, Preeti K., 1988- (author): Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, Stockholm, Sweden.

Patnaik, Ranjana (author): Banaras Hindu Univ, Indian Inst Technol, Sch Biomed Engn, Dept Biomat, Varanasi, Uttar Pradesh, India.

Wiklund, Lars (author): Uppsala universitet,Anestesiologi och intensivvård

Sharma, Aruna (author): Uppsala universitet,Anestesiologi och intensivvård

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Elsevier, 2021
2021
English.
In: Progress in Brain Research. - : Elsevier. - 0079-6123 .- 1875-7855. ; 266, s. 301-348, s. 301-348

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; https://urn.kb.se/re...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Military personnel are often exposed to high environmental heat associated with industrial or ambient abundance of nanoparticles (NPs) affecting brain function. We have shown that engineered metal NPs Ag and Cu exacerbate hyperthermia induced brain pathology. Thus, exploration of novel drug therapy is needed for effective neuroprotection in heat stroke intoxicated with NPs. In this investigation neuroprotective effects of cerebrolysin, a balanced composition of several neurotrophic factors and active peptides fragments exhibiting powerful antioxidant and anti-ischemic effects was examined in heat stroke after NPs intoxication. In addition, its efficacy is compared to currently used drugs in post-stroke therapies in clinics. Thus, levertiracetam, pregabalin, topiramat and valproate were compared in standard doses with cerebrolysin in heat stroke intoxicated with Cu or Ag NPs (50–60 nm, 50 mg/kg, i.p./day for 7 days). Rats were subjected to 4 h heat stress (HS) in a biological oxygen demand incubator at 38 °C (Relative Humidity 45–47%; Wind velocity 22.4–25.6 cm/s) that resulted in profound increase in oxidants Luminol, Lucigenin, Malondialdehyde and Myeloperoxidase, and a marked decrease in antioxidant Glutathione. At this time severe reductions in the cerebral blood flow (CBF) was seen together with increased blood-brain barrier (BBB) breakdown and brain edema formation. These pathophysiological responses were exacerbated in NPs treated heat-stressed animals. Pretreatment with cerebrolysin (2.5 mL/kg, i.v.) once daily for 3 days significantly attenuated the oxidative stress, BBB breakdown and brain edema and improved CBF in the heat stressed group. The other drugs were least effective on brain pathology following heat stroke. However, in NPs treated heat stressed animals 5 mL/kg conventional cerebrolysin and 2.5 mL/kg nanowired cerebrolysin is needed to attenuate oxidative stress, BBB breakdown, brain edema and to improve CBF. Interestingly, the other drugs even in higher doses used are unable to alter brain pathologies in NPs and heat stress. These observations are the first to demonstrate that cerebrolysin is the most superior antioxidant and anti-ischemic drug in NPs exposed heat stroke, not reported earlier.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)

Keyword

Cerebrolysin
Levetiracetam
Pregabalin
Topiramat
Valproate
Heat stroke
Cerebral blood flow
Brain edema
Heat exposure
Brain pathology
Neuroproetction
Nanoparticles from metals
Ag
Cu toxicity

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ref (subject category)
art (subject category)

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By the author/editor: Sharma, Hari Sha ...; Muresanu, Dafin ...; Ozkizilcik, Asya; Sahib, Seaab; Tian, Z. Ryan; Vicente Lafuente ...; show more...; Castellani, Rudy ...; Nozari, Ala; Feng, Lianyuan; Buzoianu, Anca D ...; Menon, Preeti K. ...; Patnaik, Ranjana; Wiklund, Lars; Sharma, Aruna; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

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