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Design and degradat...
Design and degradation of permanently porous vitamin C and zinc-based metal-organic framework
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Tajnšek, Tia K. (author)
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- Svensson Grape, Erik (author)
- Stockholms universitet,Institutionen för material- och miljökemi (MMK)
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- Willhammar, Tom, 1982- (author)
- Stockholms universitet,Institutionen för material- och miljökemi (MMK)
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Antonić Jelić, Tatjana (author)
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Javornik, Uroš (author)
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Dražić, Goran (author)
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Zabukovec Logar, Nataša (author)
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Mazaj, Matjaž (author)
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(creator_code:org_t)
- 2022-02-25
- 2022
- English.
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In: Communications Chemistry. - : Springer Science and Business Media LLC. - 2399-3669. ; 5:1
- Related links:
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https://doi.org/10.1...
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Bioapplication is an emerging field of metal-organic frameworks (MOF) utilization, but biocompatible MOFs with permanent porosity are still a rarity in the field. In addition, biocompatibility of MOF constituents is often overlooked when designing bioMOF systems, intended for drug delivery. Herein, we present the a Zn(II) bioMOF based on vitamin C as an independent ligand (bioNICS-1) forming a three-dimensional chiral framework with permanent microporosity. Comprehensive study of structure stability in biorelavant media in static and dynamic conditions demonstrates relatively high structure resistivity, retaining a high degree of its parent specific surface area. Robustness of the 3D framework enables a slow degradation process, resulting in controllable release of bioactive components, as confirmed by kinetic studies. BioNICS-1 can thus be considered as a suitable candidate for the design of a small drug molecule delivery system, which was demonstrated by successful loading and release of urea—a model drug for topical application—within and from the MOF pores.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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