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Immunity to SARS-Co...
Immunity to SARS-CoV-2 up to 15 months after infection
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- Marcotte, Harold (author)
- Karolinska Institutet
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Piralla, Antonio (author)
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- Zuo, Fanglei (author)
- Karolinska Institutet
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- Du, Likun (author)
- Karolinska Institutet
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Cassaniti, Irene (author)
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- Wan, Hui (author)
- Karolinska Institutet
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- Kumagai-Braesh, Makiko (author)
- Karolinska Institutet
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- Andréll, Juni (author)
- Stockholms universitet,Science for Life Laboratory (SciLifeLab),Institutionen för biokemi och biofysik
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Percivalle, Elena (author)
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Sammartino, Josè Camilla (author)
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- Wang, Yating (author)
- Karolinska Institutet
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- Vlachiotis, Stelios (author)
- Karolinska Institutet
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Attevall, Janine (author)
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Bergami, Federica (author)
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Ferrari, Alessandro (author)
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Colaneri, Marta (author)
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Vecchia, Marco (author)
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Sambo, Margherita (author)
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Zuccaro, Valentina (author)
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Asperges, Erika (author)
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Bruno, Raffaele (author)
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Oggionni, Tiberio (author)
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Meloni, Federica (author)
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- Abolhassani, Hassan (author)
- Karolinska Institutet
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Bertoglio, Federico (author)
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Schubert, Maren (author)
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Calzolai, Luigi (author)
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Varani, Luca (author)
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Hust, Michael (author)
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Xue, Yintong (author)
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- Hammarström, Lennart (author)
- Karolinska Institutet
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Baldanti, Fausto (author)
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- Pan-Hammarström, Qiang (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: iScience. - : Elsevier BV. - 2589-0042. ; 25:2
- Related links:
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https://doi.org/10.1...
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- Information concerning the longevity of immunity to SARS-CoV-2 following natural infection may have considerable implications for durability of immunity induced by vaccines. Here, we monitored the SARS-CoV-2 specific immune response in COVID-19 patients followed up to 15 months after symptoms onset. Following a peak at day 15-28 postinfection, the IgG antibody response and plasma neutralizing titers gradually decreased over time but stabilized after 6 months. Compared to G614, plasma neutralizing titers were more than 8-fold lower against variants Beta, Gamma, and Delta. SARS-CoV-2-specific memory B and T cells persisted in the majority of patients up to 15 months although a significant decrease in specific T cells, but not B cells, was observed between 6 and 15 months. Antiviral specific immunity, especially memory B cells in COVID-19 convalescent patients, is long-lasting, but some variants of concern may at least partially escape the neutralizing activity of plasma antibodies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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iScience
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- By the author/editor
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Marcotte, Harold
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Piralla, Antonio
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Zuo, Fanglei
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Du, Likun
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Cassaniti, Irene
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Wan, Hui
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show more...
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Kumagai-Braesh, ...
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Andréll, Juni
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Percivalle, Elen ...
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Sammartino, Josè ...
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Wang, Yating
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Vlachiotis, Stel ...
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Attevall, Janine
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Bergami, Federic ...
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Ferrari, Alessan ...
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Colaneri, Marta
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Vecchia, Marco
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Sambo, Margherit ...
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Zuccaro, Valenti ...
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Asperges, Erika
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Bruno, Raffaele
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Oggionni, Tiberi ...
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Meloni, Federica
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Abolhassani, Has ...
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Bertoglio, Feder ...
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Schubert, Maren
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Calzolai, Luigi
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Varani, Luca
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Hust, Michael
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Xue, Yintong
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Hammarström, Len ...
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Baldanti, Fausto
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Pan-Hammarström, ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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iScience
- By the university
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Stockholm University
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Karolinska Institutet