Search: onr:"swepub:oai:DiVA.org:su-203445" > Reduced reproductiv...
Fältnamn | Indikatorer | Metadata |
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000 | 03798naa a2200481 4500 | |
001 | oai:DiVA.org:su-203445 | |
003 | SwePub | |
008 | 220411s2022 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:uu-513107 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-2034452 URI |
024 | 7 | a https://doi.org/10.1038/s41586-022-04549-92 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5131072 URI |
040 | a (SwePub)sud (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Gardner, Eugene J.4 aut |
245 | 1 0 | a Reduced reproductive success is associated with selective constraint on human genes |
264 | c 2022-03-23 | |
264 | 1 | b Springer Science and Business Media LLC,c 2022 |
338 | a print2 rdacarrier | |
520 | a Genome-wide sequencing of human populations has revealed substantial variation among genes in the intensity of purifying selection acting on damaging genetic variants1. Although genes under the strongest selective constraint are highly enriched for associations with Mendelian disorders, most of these genes are not associated with disease and therefore the nature of the selection acting on them is not known2. Here we show that genetic variants that damage these genes are associated with markedly reduced reproductive success, primarily owing to increased childlessness, with a stronger effect in males than in females. We present evidence that increased childlessness is probably mediated by genetically associated cognitive and behavioural traits, which may mean that male carriers are less likely to find reproductive partners. This reduction in reproductive success may account for 20% of purifying selection against heterozygous variants that ablate protein-coding genes. Although this genetic association may only account for a very minor fraction of the overall likelihood of being childless (less than 1%), especially when compared to more influential sociodemographic factors, it may influence how genes evolve over time. | |
650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
650 | 7 | a SAMHÄLLSVETENSKAPx Sociologi0 (SwePub)5042 hsv//swe |
650 | 7 | a SOCIAL SCIENCESx Sociology0 (SwePub)5042 hsv//eng |
650 | 7 | a LANTBRUKSVETENSKAPERx Bioteknologi med applikationer på växter och djur0 (SwePub)4042 hsv//swe |
650 | 7 | a AGRICULTURAL SCIENCESx Agricultural Biotechnology0 (SwePub)4042 hsv//eng |
700 | 1 | a Neville, Matthew D. C.4 aut |
700 | 1 | a Samocha, Kaitlin E.4 aut |
700 | 1 | a Barclay, Kieron,d 1986-u Uppsala universitet,Stockholms universitet,Sociologiska institutionen,Max Planck Institute for Demographic Research, Germany; Swedish Collegium for Advanced Study, Sweden,Kollegiet för avancerade studier (SCAS),Max Planck Institute for Demographic Research, Rostock, Germany;Demography Unit, Department of Sociology, Stockholm University, Stockholm, Sweden4 aut0 (Swepub:su)kbarc |
700 | 1 | a Kolk, Martin,d 1986-u Stockholms universitet,Sociologiska institutionen4 aut0 (Swepub:su)mkolk |
700 | 1 | a Niemi, Mari E. K.4 aut |
700 | 1 | a Kirov, George4 aut |
700 | 1 | a Martin, Hilary C.4 aut |
700 | 1 | a Hurles, Matthew E.4 aut |
710 | 2 | a Stockholms universitetb Sociologiska institutionen4 org |
773 | 0 | t Natured : Springer Science and Business Media LLCg 603:7903, s. 858-863q 603:7903<858-863x 0028-0836x 1476-4687 |
856 | 4 | u https://www.nature.com/articles/s41586-022-04549-9y Nature |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-203445 |
856 | 4 8 | u https://doi.org/10.1038/s41586-022-04549-9 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-513107 |
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