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DyNAMiC: A prospect...
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Nordin, KristinKarolinska Institutet,Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för integrativ medicinsk biologi (IMB),Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)
(author)
DyNAMiC: A prospective longitudinal study of dopamine and brain connectomes : A new window into cognitive aging
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-03-16
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Wiley,2022
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:su-203492
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-203492URI
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https://doi.org/10.1002/jnr.25039DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-193314URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:149081700URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Concomitant exploration of structural, functional, and neurochemical brain mechanisms underlying age-related cognitive decline is crucial in promoting healthy aging. Here, we present the DopamiNe, Age, connectoMe, and Cognition (DyNAMiC) project, a multimodal, prospective 5-year longitudinal study spanning the adult human lifespan. DyNAMiC examines age-related changes in the brain’s structural and functional connectome in relation to changes in dopamine D1 receptor availability (D1DR), and their associations to cognitive decline. Critically, due to the complete lack of longitudinal D1DR data, the true trajectory of one of the most age-sensitive dopamine systems remains unknown. The first DyNAMiC wave included 180 healthy participants (20–80 years). Brain imaging included magnetic resonance imaging assessing brain structure (white matter, gray matter, iron), perfusion, and function (during rest and task), and positron emission tomography (PET) with the [11C]SCH23390 radioligand. A subsample (n = 20, >65 years) was additionally scanned with [11C]raclopride PET measuring D2DR. Age-related variation was evident for multiple modalities, such as D1DR; D2DR, and performance across the domains of episodic memory, working memory, and perceptual speed. Initial analyses demonstrated an inverted u-shaped association between D1DR and resting-state functional connectivity across cortical network nodes, such that regions with intermediate D1DR levels showed the highest levels of nodal strength. Evident within each age group, this is the first observation of such an association across the adult lifespan, suggesting that emergent functional architecture depends on underlying D1DR systems. Taken together, DyNAMiC is the largest D1DR study worldwide, and will enable a comprehensive examination of brain mechanisms underlying age-related cognitive decline.
Subject headings and genre
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Gorbach, Tetiana,1991-Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för integrativ medicinsk biologi (IMB),Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Statistik(Swepub:umu)gote0002
(author)
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Pedersen, RobinUmeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för integrativ medicinsk biologi (IMB),Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)(Swepub:umu)rope0055
(author)
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Panes Lundmark, VaniaUmeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för integrativ medicinsk biologi (IMB)(Swepub:umu)vapa0002
(author)
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Johansson, JarkkoUmeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Diagnostisk radiologi(Swepub:umu)jajo0061
(author)
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Andersson, MicaelUmeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för integrativ medicinsk biologi (IMB)(Swepub:umu)mian0001
(author)
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McNulty, CharlotteUmeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för integrativ medicinsk biologi (IMB),Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)(Swepub:umu)chmc0011
(author)
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Riklund, Katrine,MD, PhD, Professor,1963-Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Diagnostisk radiologi(Swepub:umu)kaah0001
(author)
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Wåhlin, AndersUmeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Radiofysik(Swepub:umu)arswan02
(author)
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Papenberg, GoranKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Aging Research Center, Karolinska Institutet & Stockholm University, Stockholm, Sweden
(author)
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Kalpouzos, GrégoriaKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Aging Research Center, Karolinska Institutet & Stockholm University, Stockholm, Sweden
(author)
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Bäckman, LarsKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Aging Research Center, Karolinska Institutet & Stockholm University, Stockholm, Sweden
(author)
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Salami, AlirezaKarolinska Institutet,Umeå universitet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Umeå University, Sweden,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för integrativ medicinsk biologi (IMB),Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Aging Research Center, Karolinska Institutet & Stockholm University, Stockholm, Sweden(Swepub:umu)alsa0014
(author)
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Umeå universitetUmeå centrum för funktionell hjärnavbildning (UFBI)
(creator_code:org_t)
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In:Journal of Neuroscience Research: Wiley100:6, s. 1296-13200360-40121097-4547
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