Search: onr:"swepub:oai:DiVA.org:su-204373" >
Plasmodium falcipar...
Plasmodium falciparum-Specific Memory B-Cell and Antibody Responses Are Associated With Immunity in Children Living in an Endemic Area of Kenya
-
Jahnmatz, Peter (author)
-
Nyabundi, Diana (author)
-
- Sundling, Christopher (author)
- Karolinska Institutet
-
show more...
-
- Widman, Linnea (author)
- Karolinska Institutet
-
Mwacharo, Jedidah (author)
-
Musyoki, Jennifer (author)
-
Otieno, Edward (author)
-
- Ahlborg, Niklas (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Mabtech AB, Sweden
-
Bejon, Philip (author)
-
Ndungu, Francis M. (author)
-
- Färnert, Anna (author)
- Karolinska Institutet
-
show less...
-
(creator_code:org_t)
- 2022-03-09
- 2022
- English.
-
In: Frontiers in Immunology. - : Frontiers Media SA. - 1664-3224. ; 13
- Related links:
-
https://doi.org/10.3...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Identifying the mechanism of naturally acquired immunity against Plasmodium falciparum malaria could contribute to the design of effective malaria vaccines. Using a recently developed multiplexed FluoroSpot assay, we assessed cross-sectional pre-existing memory B-cells (MBCs) and antibody responses against six well known P. falciparum antigens (MSP-119, MSP-2 (3D7), MSP-2 (FC27), MSP-3, AMA-1 and CSP) and measured their associations with previous infections and time to clinical malaria in the ensuing malaria season in Kenyan children. These children were under active weekly surveillance for malaria as part of a long-term longitudinal malaria immunology cohort study, where they are recruited from birth. After performing Cox regression analysis, we found that children with a breadth of three or more antigen-specific MBC or antibody responses at the baseline had a reduced risk for malaria in the ensuing P. falciparum transmission season. Specifically, MBC responses against AMA-1, MSP-2 (3D7) and MSP-3, as well as antibody responses to MSP-2 (3D7) and MSP-3 were prospectively associated with a reduced risk for malaria. The magnitude or breadth of MBC responses were however not correlated with the cumulative number of malaria episodes since birth. We conclude that increased breadth for merozoite antigen-specific MBC and antibody responses is associated with protection against malaria.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- P
- falciparum malaria
- recombinant antigens
- memory B-cells
- antibodies
- FluoroSpot
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Jahnmatz, Peter
-
Nyabundi, Diana
-
Sundling, Christ ...
-
Widman, Linnea
-
Mwacharo, Jedida ...
-
Musyoki, Jennife ...
-
show more...
-
Otieno, Edward
-
Ahlborg, Niklas
-
Bejon, Philip
-
Ndungu, Francis ...
-
Färnert, Anna
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
- Articles in the publication
-
Frontiers in Imm ...
- By the university
-
Stockholm University
-
Karolinska Institutet