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Macromolecular Vira...
Macromolecular Viral Entry Inhibitors as Broad-Spectrum First-Line Antivirals with Activity against SARS-CoV-2
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Groß, Rüdiger (author)
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Dias Loiola, Lívia Mesquita (author)
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Issmail, Leila (author)
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Uhlig, Nadja (author)
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Eberlein, Valentina (author)
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Conzelmann, Carina (author)
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Olari, Lia-Raluca (author)
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Rauch, Lena (author)
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Lawrenz, Jan (author)
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Weil, Tatjana (author)
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Müller, Janis A. (author)
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Cardoso, Mateus Borba (author)
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Gilg, Andrea (author)
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Larsson, Olivia (author)
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Höglund, Urban (author)
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- Axberg Pålsson, Sandra, 1991- (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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Tvilum, Anna Selch (author)
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Løvschall, Kaja Borup (author)
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Kristensen, Maria M. (author)
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- Spetz, Anna-Lena, 1947- (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
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Hontonnou, Fortune (author)
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Galloux, Marie (author)
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Grunwald, Thomas (author)
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Zelikin, Alexander N. (author)
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Münch, Jan (author)
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(creator_code:org_t)
- 2022-05-11
- 2022
- English.
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In: Advanced Science. - : Wiley. - 2198-3844. ; 9:20
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Inhibitors of viral cell entry based on poly(styrene sulfonate) and its core–shell nanoformulations based on gold nanoparticles are investigated against a panel of viruses, including clinical isolates of SARS-CoV-2. Macromolecular inhibitors are shown to exhibit the highly sought-after broad-spectrum antiviral activity, which covers most analyzed enveloped viruses and all of the variants of concern for SARS-CoV-2 tested. The inhibitory activity is quantified in vitro in appropriate cell culture models and for respiratory viral pathogens (respiratory syncytial virus and SARS-CoV-2) in mice. Results of this study comprise a significant step along the translational path of macromolecular inhibitors of virus cell entry, specifically against enveloped respiratory viruses.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- broad-spectrum antivirals
- entry inhibitors
- in vivo
- macromolecules
- polyanions
- respiratory syncytial virus (RSV)
- SARS-CoV-2
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Groß, Rüdiger
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Dias Loiola, Lív ...
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Issmail, Leila
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Uhlig, Nadja
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Eberlein, Valent ...
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Conzelmann, Cari ...
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show more...
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Olari, Lia-Raluc ...
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Rauch, Lena
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Lawrenz, Jan
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Weil, Tatjana
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Müller, Janis A.
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Cardoso, Mateus ...
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Gilg, Andrea
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Larsson, Olivia
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Höglund, Urban
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Axberg Pålsson, ...
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Tvilum, Anna Sel ...
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Løvschall, Kaja ...
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Kristensen, Mari ...
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Spetz, Anna-Lena ...
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Hontonnou, Fortu ...
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Galloux, Marie
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Grunwald, Thomas
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Zelikin, Alexand ...
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Münch, Jan
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Advanced Science
- By the university
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Stockholm University