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  • Groß, Rüdiger (author)

Macromolecular Viral Entry Inhibitors as Broad-Spectrum First-Line Antivirals with Activity against SARS-CoV-2

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-05-11
  • Wiley,2022
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:su-204939
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-204939URI
  • https://doi.org/10.1002/advs.202201378DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Inhibitors of viral cell entry based on poly(styrene sulfonate) and its core–shell nanoformulations based on gold nanoparticles are investigated against a panel of viruses, including clinical isolates of SARS-CoV-2. Macromolecular inhibitors are shown to exhibit the highly sought-after broad-spectrum antiviral activity, which covers most analyzed enveloped viruses and all of the variants of concern for SARS-CoV-2 tested. The inhibitory activity is quantified in vitro in appropriate cell culture models and for respiratory viral pathogens (respiratory syncytial virus and SARS-CoV-2) in mice. Results of this study comprise a significant step along the translational path of macromolecular inhibitors of virus cell entry, specifically against enveloped respiratory viruses. 

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Dias Loiola, Lívia Mesquita (author)
  • Issmail, Leila (author)
  • Uhlig, Nadja (author)
  • Eberlein, Valentina (author)
  • Conzelmann, Carina (author)
  • Olari, Lia-Raluca (author)
  • Rauch, Lena (author)
  • Lawrenz, Jan (author)
  • Weil, Tatjana (author)
  • Müller, Janis A. (author)
  • Cardoso, Mateus Borba (author)
  • Gilg, Andrea (author)
  • Larsson, Olivia (author)
  • Höglund, Urban (author)
  • Axberg Pålsson, Sandra,1991-Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut(Swepub:su)sapa8421 (author)
  • Tvilum, Anna Selch (author)
  • Løvschall, Kaja Borup (author)
  • Kristensen, Maria M. (author)
  • Spetz, Anna-Lena,1947-Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut(Swepub:su)aspet (author)
  • Hontonnou, Fortune (author)
  • Galloux, Marie (author)
  • Grunwald, Thomas (author)
  • Zelikin, Alexander N. (author)
  • Münch, Jan (author)
  • Stockholms universitetInstitutionen för molekylär biovetenskap, Wenner-Grens institut (creator_code:org_t)

Related titles

  • In:Advanced Science: Wiley9:202198-3844

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