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- Järver, PeterStockholms universitet,Institutionen för neurokemi,University of Tartu, Estonia (author)
Co-transduction of Sleeping Beauty Transposase and Donor Plasmid via a Cell-penetrating Peptide : A simple one-step method
- Article/chapterEnglish2008
Publisher, publication year, extent ...
- 2007-09-08
- Springer Science and Business Media LLC,2008
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:su-20685
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-20685URI
- https://doi.org/10.1007/s10989-007-9114-zDOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
Classification
Notes
- Transposable elements have emerged as a promising candidate for human non-viral gene-therapy. The Tc1/mariner transposon Sleeping Beauty is to date one of the most efficient transposons in mammals. Sleeping Beauty transposase has so far mostly been delivered to cells via a DNA source. This might cause spontaneous integration of the transposase gene and cause fatal damage to the affected cell. Hence, it would be advantageous to employ a non-genetic source for the transposase. We here show that a novel Cell-penetrating peptide, M918, has the ability to facilitate cellular delivery of both the transposase Sleeping Beauty as a protein and a transposon donor-plasmid carrying an antibiotic resistance gene in vitro. The technique is a simple and straightforward one-step method that might render a safe and efficient delivery platform for Sleeping Beauty mediated gene therapy.
Subject headings and genre
- NATURVETENSKAP Biologi hsv//swe
- NATURAL SCIENCES Biological Sciences hsv//eng
- NATURVETENSKAP Kemi hsv//swe
- NATURAL SCIENCES Chemical Sciences hsv//eng
- Cell-penetrating peptides
- Protein delivery
- Transfection
- Transposons
- Chemistry
- Kemi
- neurokemi med molekylär neurobiologi
- Neurochemistry with Molecular Neurobiology
Added entries (persons, corporate bodies, meetings, titles ...)
- Fernaeus, SandraStockholms universitet,Institutionen för neurokemi (author)
- EL Andaloussi, SamirStockholms universitet,Institutionen för neurokemi (author)
- Tjörnhammar, Marie-LouiseStockholms universitet,Institutionen för neurokemi(Swepub:su)mtj (author)
- Langel, ÜloStockholms universitet,Institutionen för neurokemi(Swepub:su)ulo (author)
- Stockholms universitetInstitutionen för neurokemi (creator_code:org_t)
Related titles
- In:International journal of peptide research and therapeutics: Springer Science and Business Media LLC14:1, s. 58-631573-39041573-3149
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