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Efficacy of a food ...
Efficacy of a food supplement based on S-adenosyl methionine and probiotic strains in subjects with subthreshold depression and mild-to-moderate depression : A monocentric, randomized, cross-over, double-blind, placebo-controlled clinical trial
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- Ullah, Hammad (author)
- Univ Naples Feder II, Dept Pharm, via Domenico Montesano 49, I-80131 Naples, Italy.
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- Di Minno, Alessandro (author)
- Univ Naples Feder II, Dept Pharm, via Domenico Montesano 49, I-80131 Naples, Italy.;CEINGE Biotecnol Avanzate, Via Gaetano Salvatore 486, I-80145 Naples, Italy.
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- Esposito, Cristina (author)
- Univ Naples Feder II, Dept Pharm, via Domenico Montesano 49, I-80131 Naples, Italy.
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- El-Seedi, Hesham (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Peoples R China.
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- Khalifa, Shaden A. M. (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, S-10691 Stockholm, Sweden.
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- Baldi, Alessandra (author)
- Univ Naples Feder II, Dept Pharm, via Domenico Montesano 49, I-80131 Naples, Italy.
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- Greco, Agostino (author)
- ASL Caserta, Via P Harris, I-81100 Caserta, Italy.
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- Santonastaso, Salvatore (author)
- ASL Caserta, Via P Harris, I-81100 Caserta, Italy.
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- Cioffi, Valeria (author)
- SiPGI Postgrad Sch Integrated Gestalt Psychotherap, Via Vittorio Veneto 240, I-80058 Torre Annunziata, Italy.
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- Sperandeo, Raffaele (author)
- SiPGI Postgrad Sch Integrated Gestalt Psychotherap, Via Vittorio Veneto 240, I-80058 Torre Annunziata, Italy.
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- Sacchi, Roberto (author)
- Univ Pavia, Dept Earth & Environm Sci, Appl Stat Unit, viale Taramelli 24, I-27100 Pavia, Italy.
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- Daglia, Maria (author)
- Univ Naples Feder II, Dept Pharm, via Domenico Montesano 49, I-80131 Naples, Italy.;Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Peoples R China.
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Univ Naples Feder II, Dept Pharm, via Domenico Montesano 49, I-80131 Naples, Italy Univ Naples Feder II, Dept Pharm, via Domenico Montesano 49, I-80131 Naples, Italy.;CEINGE Biotecnol Avanzate, Via Gaetano Salvatore 486, I-80145 Naples, Italy. (creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: Biomedicine and Pharmacotherapy. - : Elsevier BV. - 0753-3322 .- 1950-6007. ; 156
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Abstract
Subject headings
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- Depression is one of the most serious chronic psychiatric disorders affecting people worldwide. Subthreshold depression (SD) is a form of subclinical depression with increased risk of major depressive disorder (MDD). Patients diagnosed with SD may not be eligible for antidepressant drugs and, particularly in the case of MDD, these antidepressants may have adverse effects which outweigh their therapeutic effects, leading to discontinuation of therapy. Food supplements could provide an alternative strategy. The aim of this study is to demonstrate the efficacy of a food supplement based on a combination of S-adenosyl methionine (SAMe, 200 mg/day) and probiotics (Lactobacillus helveticus Rosell®−52, Bifidobacterium longum Rosell®−175, 3 ×109 CFU/day) in reducing depression symptoms in a monocentric, randomised, double-blind, placebo-controlled, cross-over clinical trial. 80 Subjects were recruited and offered the food supplement or placebo daily for three months, according to a cross-over clinical trial design, followed by a six-week follow-up period. The efficacy of the food supplement was measured by means of the “Hamilton Depression Rating Scale” (HAM-D) and "Patient Health Questionnaire-9" (PHQ-9), using a mixed analysis of variance model, with random intercept, for statistical analysis. The food supplement showed a significant decrease of PHQ-9 and HAM-D scores resulting in reduced SD and MDD symptoms as compared to placebo. In conclusion, the daily intake of the food supplement based on SAMe and probiotic strains for a period of three months is effective in improving the quality of life of SD subjects who are not eligible for antidepressant therapies, and patients suffering from mild-to-moderate depression who are not sensitive or cannot tolerate conventional drugs.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Food supplement
- Mild-to-moderate depression
- Probiotics
- S-adenosylmethionine
- Subthreshold depression
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ullah, Hammad
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Di Minno, Alessa ...
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Esposito, Cristi ...
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El-Seedi, Hesham
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Khalifa, Shaden ...
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Baldi, Alessandr ...
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show more...
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Greco, Agostino
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Santonastaso, Sa ...
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Cioffi, Valeria
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Sperandeo, Raffa ...
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Sacchi, Roberto
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Daglia, Maria
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Biomedicine and ...
- By the university
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Stockholm University
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Uppsala University