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Evolutionary conseq...
Evolutionary consequences of genomic deletions and insertions in the woolly mammoth genome
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- van der Valk, Tom (author)
- Swedish Museum of Natural History
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- Dehasque, Marianne (author)
- Stockholm University,Stockholms universitet,Zoologiska institutionen,Swedish Museum of Natural History, Sweden
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- Chacón-Duque, J. Camilo (author)
- Stockholm University,Stockholms universitet,Institutionen för arkeologi och antikens kultur
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- Oskolkov, Nikolay (author)
- Lund University,Lunds universitet,MEMEG,Biologiska institutionen,Naturvetenskapliga fakulteten,LTH profilområde: Teknik för hälsa,LTH profilområden,Lunds Tekniska Högskola,Department of Biology,Faculty of Science,LTH Profile Area: Engineering Health,LTH Profile areas,Faculty of Engineering, LTH
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- Vartanyan, Sergey (author)
- North-East Interdisciplinary Scientific Research Institute of Far East Branch of the Russian Academy of Sciences
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- Heintzman, Peter D. (author)
- UiT The Arctic University of Norway, Tromsø
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- Pečnerová, Patrícia (author)
- University of Copenhagen
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- Díez-del-Molino, David (author)
- Stockholm University,Stockholms universitet,Zoologiska institutionen,Swedish Museum of Natural History, Sweden
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- Dalén, Love, 1980- (author)
- Stockholm University,Stockholms universitet,Zoologiska institutionen,Swedish Museum of Natural History, Sweden
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- English.
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In: iScience. - : Elsevier BV. - 2589-0042. ; 25:8
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Abstract
Subject headings
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- Woolly mammoths had a set of adaptations that enabled them to thrive in the Arctic environment. Many mammoth-specific single nucleotide polymorphisms (SNPs) responsible for unique mammoth traits have been previously identified from ancient genomes. However, a multitude of other genetic variants likely contributed to woolly mammoth evolution. In this study, we sequenced two woolly mammoth genomes and combined these with previously sequenced mammoth and elephant genomes to conduct a survey of mammoth-specific deletions and indels. We find that deletions are highly enriched in non-coding regions, suggesting selection against structural variants that affect protein sequences. Nonetheless, at least 87 woolly mammoth genes contain deletions or indels that modify the coding sequence, including genes involved in skeletal morphology and hair growth. These results suggest that deletions and indels contributed to the unique phenotypic adaptations of the woolly mammoth, and were potentially critical to surviving in its natural environment.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Keyword
- Bioinformatics
- Biological sciences
- Evolutionary biology
- Natural sciences
- Phylogenetics
- Zoology
- Bioinformatics
- Biological sciences
- Evolutionary biology
- Natural sciences
- Phylogenetics
- Zoology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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van der Valk, To ...
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Dehasque, Marian ...
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Chacón-Duque, J. ...
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Oskolkov, Nikola ...
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Vartanyan, Serge ...
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Heintzman, Peter ...
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show more...
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Pečnerová, Patrí ...
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Díez-del-Molino, ...
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Dalén, Love, 198 ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
- Articles in the publication
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iScience
- By the university
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Stockholm University
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Lund University