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Serum Fc-Mediated M...
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Vangeti, Sindhu,1989-Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Icahn School of Medicine at Mount Sinai, USA
(author)
Serum Fc-Mediated Monocyte Phagocytosis Activity Is Stable for Several Months after SARS-CoV-2 Asymptomatic and Mildly Symptomatic Infection
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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American Society for Microbiology,2022
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Numbers
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LIBRIS-ID:oai:DiVA.org:su-212584
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-212584URI
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https://doi.org/10.1128/spectrum.01837-22DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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We investigated the temporal profile of multiple components of the serological response after asymptomatic or mildly symptomatic SARS-CoV-2 infection, in a cohort of 67 previously SARS-CoV-2 naive young adults, up to 8.5 months after infection. We found a significant decrease of spike IgG and neutralization antibody titers from early (11 to 56 days) to late (4 to 8.5 months) time points postinfection. Over the study period, S1-specific IgG levels declined significantly faster than that of the S2-specific IgG. Further, serum antibodies from PCR-confirmed participants cross-recognized S2, but not S1, of the betacoronaviruses HKU1 and OC43, suggesting a greater degree of cross-reactivity of S2 among betacoronaviruses. Antibody-Dependent Natural Killer cell Activation (ADNKA) was detected at the early time point but significantly decreased at the late time point. Induction of serum Antibody-Dependent Monocyte Phagocytosis (ADMP) was detected in all the infected participants, and its levels remained stable over time. Additionally, a reduced percentage of participants had detectable neutralizing activity against the Beta (50%), Gamma (61 to 67%), and Delta (90 to 94%) variants, both early and late postinfection, compared to the ancestral strain (100%). Antibody binding to S1 and RBD of Beta, Gamma, Delta (1.7 to 2.3-fold decrease), and Omicron (10 to 16-fold decrease) variants was also significantly reduced compared to the ancestral SARS-CoV-2 strain. Overall, we found variable temporal profiles of specific components and functionality of the serological response to SARS-CoV-2 in young adults, which is characterized by lasting, but decreased, neutralizing activity and antibody binding to S1, stable ADMP activity, and relatively stable S2-specific IgG levels.
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Periasamy, Sivakumar
(author)
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Sun, Peifang
(author)
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Balinsky, Corey A.
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Mahajan, Avinash S.
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Kuzmina, Natalia A.
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Soares-Schanoski, Alessandra
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Cooper, Elizabeth
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Beckett, Charmagne
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Marayag, Jan
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Marrone, Amethyst
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Nunez, Edgar
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Ge, Yongchao
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Porter, Chad K.
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Goforth, Carl W.
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Lizewski, Stephen E.
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Lizewski, Rhonda
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Jani, Vihasi
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Sugiharto, Victor A.
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Schilling, Megan
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Yu, Xuechen B.
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Marjanovic, Nada
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George, Mary Catherine
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Bukreyev, Alexander
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Sealfon, Stuart C.
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Letizia, Andrew G.
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Ramos, Irene
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Stockholms universitetInstitutionen för molekylär biovetenskap, Wenner-Grens institut
(creator_code:org_t)
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In:Microbiology Spectrum: American Society for Microbiology10:62165-0497
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Vangeti, Sindhu, ...
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Periasamy, Sivak ...
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Sun, Peifang
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Balinsky, Corey ...
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Mahajan, Avinash ...
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Kuzmina, Natalia ...
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Soares-Schanoski ...
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Cooper, Elizabet ...
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Marayag, Jan
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Marrone, Amethys ...
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Nunez, Edgar
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Ge, Yongchao
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Porter, Chad K.
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Goforth, Carl W.
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Lizewski, Stephe ...
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Lizewski, Rhonda
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Jani, Vihasi
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Sugiharto, Victo ...
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Schilling, Megan
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Yu, Xuechen B.
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Marjanovic, Nada
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George, Mary Cat ...
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