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Long-term air pollu...
Long-term air pollution exposure and Parkinson's disease mortality in a large pooled European cohort : An ELAPSE study
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Cole-Hunter, Thomas (author)
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Zhang, Jiawei (author)
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So, Rina (author)
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Samoli, Evangelia (author)
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Liu, Shuo (author)
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Chen, Jie (author)
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Strak, Maciej (author)
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Wolf, Kathrin (author)
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Weinmayr, Gudrun (author)
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Rodopolou, Sophia (author)
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Remfry, Elizabeth (author)
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de Hoogh, Kees (author)
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- Bellander, Tom (author)
- Karolinska Institutet
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Brandt, Jørgen (author)
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Concin, Hans (author)
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Zitt, Emanuel (author)
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Fecht, Daniela (author)
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Forastiere, Francesco (author)
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Gulliver, John (author)
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Hoffmann, Barbara (author)
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Hvidtfeldt, Ulla A. (author)
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Jöckel, Karl-Heinz (author)
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Mortensen, Laust H. (author)
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Ketzel, Matthias (author)
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- Méndez, Diego Yacamán (author)
- Karolinska Institutet
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- Leander, Karin (author)
- Karolinska Institutet
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- Ljungman, Petter (author)
- Karolinska Institutet
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Faure, Elodie (author)
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Lee, Pei-Chen (author)
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Elbaz, Alexis (author)
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- Magnusson, Patrik K. E. (author)
- Karolinska Institutet
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Nagel, Gabriele (author)
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- Pershagen, Göran (author)
- Karolinska Institutet
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Peters, Annette (author)
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- Rizzuto, Debora (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Stockholm Gerontology Research Center, Sweden
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Vermeulen, Roel C. H. (author)
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Schramm, Sara (author)
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Stafoggia, Massimo (author)
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Katsouyanni, Klea (author)
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Brunekreef, Bert (author)
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Hoek, Gerard (author)
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Lim, Youn-Hee (author)
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Andersen, Zorana J. (author)
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(creator_code:org_t)
- Elsevier BV, 2023
- 2023
- English.
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In: Environment International. - : Elsevier BV. - 0160-4120 .- 1873-6750. ; 171
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: The link between exposure to ambient air pollution and mortality from cardiorespiratory diseases is well established, while evidence on neurodegenerative disorders including Parkinson’s Disease (PD) remains limited.Objective: We examined the association between long-term exposure to ambient air pollution and PD mortality in seven European cohorts.Methods: Within the project ‘Effects of Low-Level Air Pollution: A Study in Europe’ (ELAPSE), we pooled data from seven cohorts among six European countries. Annual mean residential concentrations of fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon (BC), and ozone (O3), as well as 8 PM2.5 components (copper, iron, potassium, nickel, sulphur, silicon, vanadium, zinc), for 2010 were estimated using Europe-wide hybrid land use regression models. PD mortality was defined as underlying cause of death being either PD, secondary Parkinsonism, or dementia in PD. We applied Cox proportional hazard models to investigate the associations between air pollution and PD mortality, adjusting for potential confounders.Results: Of 271,720 cohort participants, 381 died from PD during 19.7 years of follow-up. In single-pollutant analyses, we observed positive associations between PD mortality and PM2.5 (hazard ratio per 5 µg/m3: 1.25; 95% confidence interval: 1.01–1.55), NO2 (1.13; 0.95–1.34 per 10 µg/m3), and BC (1.12; 0.94–1.34 per 0.5 × 10-5m-1), and a negative association with O3 (0.74; 0.58–0.94 per 10 µg/m3). Associations of PM2.5, NO2, and BC with PD mortality were linear without apparent lower thresholds. In two-pollutant models, associations with PM2.5 remained robust when adjusted for NO2 (1.24; 0.95–1.62) or BC (1.28; 0.96–1.71), whereas associations with NO2 or BC attenuated to null. O3 associations remained negative, but no longer statistically significant in models with PM2.5. We detected suggestive positive associations with the potassium component of PM2.5.Conclusion: Long-term exposure to PM2.5, at levels well below current EU air pollution limit values, may contribute to PD mortality.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- Air pollution
- Adults
- Parkinson's Disease
- Long-term exposure
- Low-level exposure
- Pooled-cohort study
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Cole-Hunter, Tho ...
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Zhang, Jiawei
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So, Rina
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Samoli, Evangeli ...
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Liu, Shuo
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Chen, Jie
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show more...
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Strak, Maciej
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Wolf, Kathrin
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Weinmayr, Gudrun
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Rodopolou, Sophi ...
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Remfry, Elizabet ...
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de Hoogh, Kees
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Bellander, Tom
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Brandt, Jørgen
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Concin, Hans
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Zitt, Emanuel
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Fecht, Daniela
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Forastiere, Fran ...
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Gulliver, John
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Hoffmann, Barbar ...
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Hvidtfeldt, Ulla ...
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Jöckel, Karl-Hei ...
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Mortensen, Laust ...
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Ketzel, Matthias
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Méndez, Diego Ya ...
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Leander, Karin
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Ljungman, Petter
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Faure, Elodie
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Lee, Pei-Chen
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Elbaz, Alexis
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Magnusson, Patri ...
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Nagel, Gabriele
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Pershagen, Göran
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Peters, Annette
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Rizzuto, Debora
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Vermeulen, Roel ...
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Schramm, Sara
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Stafoggia, Massi ...
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Katsouyanni, Kle ...
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Brunekreef, Bert
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Hoek, Gerard
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Lim, Youn-Hee
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Andersen, Zorana ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
- Articles in the publication
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Environment Inte ...
- By the university
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Stockholm University
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Karolinska Institutet