Modular Synthesis of (Borylmethyl)silanes through Orthogonal Functionalization of a Carbon Atom

Chowdhury, Rajdip,1993-Stockholms universitet,Institutionen för organisk kemi (author)

(Borylmethyl)trimethylsilanes are important building blocks in organic synthesis displaying a unique reactivity. Yet, the synthesis of more advanced derivatives is limited by the advanced silicon intermediates required for their preparation. Herein, a one-pot synthesis of (borylmethyl)silanes is developed, sourced on available alkyl-, aryl-, alkoxy-, aryloxy-, and silyl-hydrosilane materials. The privileged reactivity of N-hydroxyphthalimidyl diazoacetate (NHPI-DA) in Si–H insertion and α-silyl redox-active esters in different decarboxylative borylation reactions are scrutinized.

Elek, Gábor ZoltánStockholms universitet,Institutionen för organisk kemi,Tallinn University of Technology, Estonia(Swepub:su)gael2454 (author)
Meana-Baamonde, BeatrizStockholms universitet,Institutionen för organisk kemi,University of Valencia, Spain(Swepub:su)beme7015 (author)
Mendoza, AbrahamStockholms universitet,Institutionen för organisk kemi,University of Valencia, Spain(Swepub:su)amend (author)
Stockholms universitetInstitutionen för organisk kemi (creator_code:org_t)

In:Organic Letters: American Chemical Society (ACS)25:11, s. 1935-19401523-70601523-7052

By the author/editor: Chowdhury, Rajdi ...; Elek, Gábor Zolt ...; Meana-Baamonde, ...; Mendoza, Abraham

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