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Triglyceride-glucos...
Triglyceride-glucose index, Alzheimer's disease plasma biomarkers, and dementia in older adults : The MIND-China study
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Tian, Na (author)
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Fa, Wenxin (author)
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Dong, Yi (author)
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show more...
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Liu, Rui (author)
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- Liu, Cuicui (author)
- Karolinska Institutet
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Liu, Keke (author)
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Mao, Ming (author)
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Zhu, Min (author)
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Liang, Xiaoyan (author)
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Wang, Nan (author)
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Ma, Yixun (author)
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Ngandu, Tiia (author)
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Launer, Lenore J. (author)
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- Wang, Yongxiang (author)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Shandong Provincial Hospital affiliated to Shandong First Medical University, P.R. China; Shandong Provincial Clinical Research Center for Neurological Diseases, P.R. China
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Hou, Tingting (author)
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Du, Yifeng (author)
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- Qiu, Chengxuan (author)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Shandong Provincial Hospital affiliated to Shandong First Medical University, P.R. China
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. - 2352-8729. ; 15:2
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Introduction: Population-based studies have rarely explored the associations of the triglyceride–glucose (TyG) index, a surrogate marker of insulin resistance, with dementia and plasma biomarkers for amyloid beta (Aβ) and neurodegeneration.Methods: This population-based study included 5199 participants (age ≥ 65 years); of these, plasma Aβ, total tau, and neurofilament light chain (NfL) were measured in 1287 persons. Dementia and subtypes were diagnosed following the international criteria. TyG index was calculated as ln(fasting triglyceride(mg/dL) × fasting glucose[mg/dL]/2). Data were analyzed using logistic and general linear regression models.Results: Dementia, Alzheimer's disease (AD), and vascular dementia (VaD) were diagnosed in 301, 195, and 95 individuals, respectively. A high TyG index was significantly associated with increased likelihoods of dementia and AD; the significant association with dementia remained among participants without cardiovascular disease or diabetes. In the biomarker subsample, a high TyG index was correlated with elevated plasma Aβ, but not with total tau or NfL.Discussion: High TyG index is associated with dementia, possibly via Aβ pathology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- Alzheimer's disease
- dementia
- insulin resistance
- plasma amyloid beta
- population-based study
- triglyceride-glucose index
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Tian, Na
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Fa, Wenxin
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Dong, Yi
-
Liu, Rui
-
Liu, Cuicui
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Liu, Keke
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show more...
-
Mao, Ming
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Zhu, Min
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Liang, Xiaoyan
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Wang, Nan
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Ma, Yixun
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Ngandu, Tiia
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Launer, Lenore J ...
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Wang, Yongxiang
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Hou, Tingting
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Du, Yifeng
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Qiu, Chengxuan
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
- Articles in the publication
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Alzheimer's & De ...
- By the university
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Stockholm University
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Karolinska Institutet