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Triglyceride-glucose index, Alzheimer's disease plasma biomarkers, and dementia in older adults : The MIND-China study
- Tian, Na (author)
- Fa, Wenxin (author)
- Dong, Yi (author)
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- Liu, Rui (author)
- Liu, Keke (author)
- Mao, Ming (author)
- Zhu, Min (author)
- Liang, Xiaoyan (author)
- Wang, Nan (author)
- Ma, Yixun (author)
- Ngandu, Tiia (author)
- Launer, Lenore J. (author)
- Hou, Tingting (author)
- Du, Yifeng (author)
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- (creator_code:org_t)
- 2023
- 2023
- English.
- In: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. - 2352-8729. ; 15:2
- Journal article (peer-reviewed)
Abstract
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- Introduction: Population-based studies have rarely explored the associations of the triglyceride–glucose (TyG) index, a surrogate marker of insulin resistance, with dementia and plasma biomarkers for amyloid beta (Aβ) and neurodegeneration.Methods: This population-based study included 5199 participants (age ≥ 65 years); of these, plasma Aβ, total tau, and neurofilament light chain (NfL) were measured in 1287 persons. Dementia and subtypes were diagnosed following the international criteria. TyG index was calculated as ln(fasting triglyceride(mg/dL) × fasting glucose[mg/dL]/2). Data were analyzed using logistic and general linear regression models.Results: Dementia, Alzheimer's disease (AD), and vascular dementia (VaD) were diagnosed in 301, 195, and 95 individuals, respectively. A high TyG index was significantly associated with increased likelihoods of dementia and AD; the significant association with dementia remained among participants without cardiovascular disease or diabetes. In the biomarker subsample, a high TyG index was correlated with elevated plasma Aβ, but not with total tau or NfL.Discussion: High TyG index is associated with dementia, possibly via Aβ pathology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- Alzheimer's disease
- dementia
- insulin resistance
- plasma amyloid beta
- population-based study
- triglyceride-glucose index
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- ref (subject category)
- art (subject category)
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- Tian, Na
- Fa, Wenxin
- Dong, Yi
- Liu, Rui
- Liu, Cuicui
- Liu, Keke
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- Mao, Ming
- Zhu, Min
- Liang, Xiaoyan
- Wang, Nan
- Ma, Yixun
- Ngandu, Tiia
- Launer, Lenore J ...
- Wang, Yongxiang
- Hou, Tingting
- Du, Yifeng
- Qiu, Chengxuan
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- MEDICAL AND HEALTH SCIENCES
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- Karolinska Institutet
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