Cognitive Benefit of a Multidomain Intervention for Older Adults at Risk of Cognitive Decline: A Cluster- Randomized Controlled Trial

Cognitive Benefit of a Multidomain Intervention for Older Adults at Risk of Cognitive Decline : A Cluster- Randomized Controlled Trial

Objective: We sought to assess cognitive benefits of a community-based multi -domain intervention for improving cognition among older adults at risk of cog-nitive decline (COMBAT). Design: A two-armed cluster-randomized controlled trial. Setting and Participants: Community-dwelling older adults aged 60 years or older and were at risk of cognitive decline (n = 209). Intervention: In this 9-month intervention study, 10 community hospitals in Beijing, China, were randomized (1:1) to receive either a multidomain inter-vention of meditation, cognitive training, exercise, and nutrition counseling or usual care. The intervention was delivered with weekly 1-hour group training sessions and weekly home homework. Measurements: Primary outcome was change in cognition as measured by a composite Z score of seven cognitive tests. Secondary outcomes included subjective cognitive abilities, positive and nega-tive affective experiences, physical activity, and dietary habits. Assessments were administered at baseline, end of the intervention, and 1 year after com-pleting the intervention (1-year follow-up). Results: Immediately after the intervention, the intervention group showed significant enhancement in cogni-tive performance (p = 0.026). The between-group difference in the Z score of change of cognition was 0.20 (95% CI: 0.053, 0.35), with a Hedges' g of 0.40 (95% CI: 0.29, 0.50). However, this cognitive benefit was not significant at

Ma, Zhuoya (author)
Zhu, Xinyi (author)
Zheng, Zhiwei (author)
Li, Juan (author)
Fu, Jiangning (author)
Shao, Qi (author)
Han, Xiaoyan (author)
Wang, Zhihui (author)
Wang, Xiaoning (author)
Yin, Zhaoxue (author)
Qiu, ChengxuanStockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI) (author)
Karolinska InstitutetCentrum för forskning om äldre och åldrande (ARC), (tills m KI) (creator_code:org_t)

In:The American journal of geriatric psychiatry: Elsevier BV31:3, s. 197-2091064-74811545-7214

By the author/editor: Liu, Xiaomei; Ma, Zhuoya; Zhu, Xinyi; Zheng, Zhiwei; Li, Juan; Fu, Jiangning; show more...; Shao, Qi; Han, Xiaoyan; Wang, Zhihui; Wang, Xiaoning; Yin, Zhaoxue; Qiu, Chengxuan; show less...

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