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  • Imahori, YumeStockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI) (author)

Association of ischemic heart disease with long-term risk of cognitive decline and dementia : A cohort study

  • Article/chapterEnglish2023

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  • 2023
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:su-220471
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-220471URI
  • https://doi.org/10.1002/alz.13114DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:152698344URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • INTRODUCTION: The independent and joint effect of ischemic heart disease (IHD) and coexisting atrial fibrillation (AF) and heart failure (HF) on dementia risk is largely unknown.METHODS: This population-based cohort study included 2568 dementia-free participants (age ≥60 years) in SNAC-K, who were regularly examined from 2001–2004 through 2013–2016. Dementia was diagnosed following the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) criteria. Global cognitive function was assessed using a global cognitive composite z-score derived from five cognitive domains. Data were analyzed using Cox, Fine-Gray, and linear mixed-effects models.RESULTS: Overall, IHD at baseline was associated with multivariable-adjusted hazard ratio (HR) of 1.39 (95% confidence interval = 1.06−1.82) for dementia and multivariable-adjusted β-coefficient of −0.02 (−0.03 to −0.01) for annual changes in global cognitive z-score, independent of AF, HF, and cerebrovascular disease. Coexisting AF or HF did not add further risk to dementia and cognitive decline.DISCUSSION: IHD is independently associated with dementia and cognitive decline in older adults, whereas coexisting AF/HF is not associated with an increased risk.

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  • Vetrano, Davide L.Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Stockholm Gerontology Research Center, Sweden (author)
  • Ljungman, PetterKarolinska Institutet (author)
  • Laukka, Erika J.Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Stockholm Gerontology Research Center, Sweden (author)
  • Wu, JingKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI) (author)
  • Grande, GiuliaStockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI) (author)
  • Rizzuto, DeboraKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Stockholm Gerontology Research Center, Sweden (author)
  • Fratiglioni, LauraKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Stockholm Gerontology Research Center, Sweden (author)
  • Qiu, ChengxuanKarolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI) (author)
  • Stockholms universitetCentrum för forskning om äldre och åldrande (ARC), (tills m KI) (creator_code:org_t)

Related titles

  • In:Alzheimer's & Dementia19:12, s. 5541-55491552-52601552-5279

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