onr:"swepub:oai:DiVA.org:su-22322"
Search: onr:"swepub:oai:DiVA.org:su-22322" > NMR solution struct...
- 1 of 1
- Previous record
- Next record
- To hitlist
NMR solution structure and position of transportan in neutral phospholipid bicelles.
-
- Bárány-Wallje, Elsa (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,biofysik,Astrid Gräslund
- Andersson, August (author)
- Gräslund, Astrid (author)
- show more...
- Mäler, Lena (author)
- show less...
- (creator_code:org_t)
- 2004
- 2004
- English.
- In: FEBS Lett. - 0014-5793. ; 567:2-3, s. 265-9
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Transportan is a chimeric cell-penetrating peptide constructed from the peptides galanin and mastoparan, which has the ability to internalize living cells carrying a hydrophilic load. In this study, we have determined the NMR solution structure and investigated the position of transportan in neutral bicelles. The structure revealed a well-defined -helix in the C-terminal mastoparan part of the peptide and a weaker tendency to form an -helix in the N-terminal domain. The position of the peptide in relation to the membrane, as studied by adding paramagnetic probes, shows that the peptide lies parallel to, and in the head-group region of the membrane surface. This result is supported by amide proton secondary chemical shifts.
Keyword
- Amides/chemistry
- Amino Acid Sequence
- Circular Dichroism
- Dimyristoylphosphatidylcholine/*chemistry
- Drug Carriers/chemistry
- Galanin
- Glycerophosphates/chemistry
- Lipid Bilayers/*chemistry
- Micelles
- Models; Molecular
- Molecular Sequence Data
- Nuclear Magnetic Resonance; Biomolecular/*methods
- Phospholipid Ethers/*chemistry
- Phosphorylcholine/*analogs & derivatives/chemistry
- Protein Structure; Secondary
- Protein Structure; Tertiary
- Recombinant Fusion Proteins/*chemistry
- Spin Labels
- Wasp Venoms
Publication and Content Type
- ref (subject category)
- art (subject category)
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Bárány-Wallje, E ...
- Andersson, Augus ...
- Gräslund, Astrid
- Mäler, Lena
- Articles in the publication
- FEBS Lett
- By the university
- Stockholm University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
