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Tautomerism unveils...
Tautomerism unveils a self-inhibition mechanism of crystallization
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Tang, Weiwei (author)
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- Yang, Taimin, 1991- (author)
- Stockholms universitet,Institutionen för material- och miljökemi (MMK)
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Morales-Rivera, Cristian A. (author)
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Geng, Xi (author)
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Srirambhatla, Vijay K. (author)
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Kang, Xiang (author)
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Chauhan, Vraj P. (author)
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Hong, Sungil (author)
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Tu, Qing (author)
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Florence, Alastair J. (author)
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Mo, Huaping (author)
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Calderon, Hector A. (author)
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Kisielowski, Christian (author)
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Robles Hernandez, Francisco C. (author)
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- Zou, Xiaodong (author)
- Stockholms universitet,Institutionen för material- och miljökemi (MMK)
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Mpourmpakis, Giannis (author)
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Rimer, Jeffrey D. (author)
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(creator_code:org_t)
- 2023-02-02
- 2023
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 14:1
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Modifiers are commonly used in natural, biological, and synthetic crystallization to tailor the growth of diverse materials. Here, we identify tautomers as a new class of modifiers where the dynamic interconversion between solute and its corresponding tautomer(s) produces native crystal growth inhibitors. The macroscopic and microscopic effects imposed by inhibitor-crystal interactions reveal dual mechanisms of inhibition where tautomer occlusion within crystals that leads to natural bending, tunes elastic modulus, and selectively alters the rate of crystal dissolution. Our study focuses on ammonium urate crystallization and shows that the keto-enol form of urate, which exists as a minor tautomer, is a potent inhibitor that nearly suppresses crystal growth at select solution alkalinity and supersaturation. The generalizability of this phenomenon is demonstrated for two additional tautomers with relevance to biological systems and pharmaceuticals. These findings offer potential routes in crystal engineering to strategically control the mechanical or physicochemical properties of tautomeric materials.
Subject headings
- NATURVETENSKAP -- Kemi -- Materialkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Materials Chemistry (hsv//eng)
- NATURVETENSKAP -- Biologi -- Strukturbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Structural Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Tang, Weiwei
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Yang, Taimin, 19 ...
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Morales-Rivera, ...
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Geng, Xi
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Srirambhatla, Vi ...
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Kang, Xiang
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show more...
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Chauhan, Vraj P.
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Hong, Sungil
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Tu, Qing
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Florence, Alasta ...
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Mo, Huaping
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Calderon, Hector ...
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Kisielowski, Chr ...
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Robles Hernandez ...
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Zou, Xiaodong
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Mpourmpakis, Gia ...
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Rimer, Jeffrey D ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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and Materials Chemis ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Structural Biolo ...
- Articles in the publication
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Nature Communica ...
- By the university
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Stockholm University