onr:"swepub:oai:DiVA.org:su-227424"
Search: onr:"swepub:oai:DiVA.org:su-227424" > Evolution of microR...
- 1 of 1
- Previous record
- Next record
- To hitlist
Evolution of microRNAs in Amoebozoa and implications for the origin of multicellularity
- Edelbroek, Bart (author)
- Kjellin, Jonas (author)
-
- Biryukova, Inna (author)
- Stockholms universitet,Science for Life Laboratory (SciLifeLab),Institutionen för molekylär biovetenskap, Wenner-Grens institut
- show more...
- Liao, Zhen (author)
- Lundberg, Torgny (author)
- Noegel, Angelika A. (author)
- Eichinger, Ludwig (author)
- Söderbom, Fredrik (author)
- show less...
- (creator_code:org_t)
- 2024
- 2024
- English.
- In: Nucleic Acids Research. - 0305-1048 .- 1362-4962.
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- MicroRNAs (miRNAs) are important and ubiquitous regulators of gene expression in both plants and animals. They are thought to have evolved convergently in these lineages and hypothesized to have played a role in the evolution of multicellularity. In line with this hypothesis, miRNAs have so far only been described in few unicellular eukaryotes. Here, we investigate the presence and evolution of miRNAs in Amoebozoa, focusing on species belonging to Acanthamoeba, Physarum and dictyostelid taxonomic groups, representing a range of unicellular and multicellular lifestyles. miRNAs that adhere to both the stringent plant and animal miRNA criteria were identified in all examined amoebae, expanding the total number of protists harbouring miRNAs from 7 to 15. We found conserved miRNAs between closely related species, but the majority of species feature only unique miRNAs. This shows rapid gain and/or loss of miRNAs in Amoebozoa, further illustrated by a detailed comparison between two evolutionary closely related dictyostelids. Additionally, loss of miRNAs in the Dictyostelium discoideum drnB mutant did not seem to affect multicellular development and, hence, demonstrates that the presence of miRNAs does not appear to be a strict requirement for the transition from uni- to multicellular life.
Subject headings
- NATURVETENSKAP -- Biologi -- Botanik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Botany (hsv//eng)
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Nucleic Acids Research (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Edelbroek, Bart
- Kjellin, Jonas
- Biryukova, Inna
- Liao, Zhen
- Lundberg, Torgny
- Noegel, Angelika ...
- show more...
- Eichinger, Ludwi ...
- Friedländer, Mar ...
- Söderbom, Fredri ...
- show less...
- About the subject
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
- and Botany
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
- and Evolutionary Bio ...
- Articles in the publication
- Nucleic Acids Re ...
- By the university
- Stockholm University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
