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TRAPs :
TRAPs : the 'elevator-with-an-operator' mechanism
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- Davies, James S. (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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Currie, Michael J. (author)
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Dobson, Renwick C. J. (author)
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Horne, Christopher R. (author)
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- North, Rachel A. (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,University of Sydney, Australia
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Trends in Biochemical Sciences (TIBS). - 0968-0004 .- 1362-4326. ; 49:2, s. 134-144
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Tripartite ATP -independent periplasmic (TRAP) transporters are nutrient -uptake systems found in bacteria and archaea. These evolutionary divergent transporter systems couple a substrate -binding protein (SBP) to an elevator -type secondary transporter, which is a first -of -its -kind mechanism of transport. Here, we highlight breakthrough TRAP transporter structures and recent functional data that probe the mechanism of transport. Furthermore, we discuss recent structural and biophysical studies of the ion transporter superfamily (ITS) members and highlight mechanistic principles that are relevant for further exploration of the TRAP transporter system.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
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