TRAPs: the 'elevator-with-an-operator' mechanism

Davies, James S.Stockholms universitet,Institutionen för biokemi och biofysik (author)

TRAPs : the 'elevator-with-an-operator' mechanism

Tripartite ATP -independent periplasmic (TRAP) transporters are nutrient -uptake systems found in bacteria and archaea. These evolutionary divergent transporter systems couple a substrate -binding protein (SBP) to an elevator -type secondary transporter, which is a first -of -its -kind mechanism of transport. Here, we highlight breakthrough TRAP transporter structures and recent functional data that probe the mechanism of transport. Furthermore, we discuss recent structural and biophysical studies of the ion transporter superfamily (ITS) members and highlight mechanistic principles that are relevant for further exploration of the TRAP transporter system.

Currie, Michael J. (author)
Dobson, Renwick C. J. (author)
Horne, Christopher R. (author)
North, Rachel A.Stockholms universitet,Institutionen för biokemi och biofysik,University of Sydney, Australia(Swepub:su)rano0610 (author)
Stockholms universitetInstitutionen för biokemi och biofysik (creator_code:org_t)

By the author/editor: Davies, James S.; Currie, Michael ...; Dobson, Renwick ...; Horne, Christoph ...; North, Rachel A.

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Biochemistry and ...

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