Search: onr:"swepub:oai:DiVA.org:su-228132" >
Intestinal stroma g...
Intestinal stroma guides monocyte differentiation to macrophages through GM-CSF
-
- Kvedaraite, Egle (author)
- Karolinska Institutet
-
- Lourda, Magda (author)
- Karolinska Institutet
-
Mouratidou, Natalia (author)
-
show more...
-
Düking, Tim (author)
-
- Padhi, Avinash (author)
- Karolinska Institutet
-
- Moll, Kirsten (author)
- Karolinska Institutet
-
- Czarnewski, Paulo, 1991- (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab)
-
- Sinha, Indranil (author)
- Karolinska Institutet
-
- Xagoraris, Ioanna (author)
- Karolinska Institutet
-
Kokkinou, Efthymia (author)
-
Damdimopoulos, Anastasios (author)
-
Weigel, Whitney (author)
-
Hartwig, Olga (author)
-
Santos, Telma E. (author)
-
- Soini, Tea (author)
- Karolinska Institutet
-
Van Acker, Aline (author)
-
Rahkonen, Nelly (author)
-
Flodström Tullberg, Malin (author)
-
- Ringqvist, Emma (author)
- Karolinska Institutet
-
- Buggert, Marcus (author)
- Karolinska Institutet
-
- Jorns, Carl (author)
- Karolinska Institutet
-
- Lindforss, Ulrik (author)
- Karolinska Institutet
-
- Nordenvall, Caroline (author)
- Karolinska Institutet
-
- Stamper, Christopher T. (author)
- Karolinska Institutet
-
- Jess, David Unnersjö (author)
- KTH,Biofysik,Science for Life Laboratory, SciLifeLab
-
Akber, Mira (author)
-
Nadisauskaite, Ruta (author)
-
- Jansson, Jessica (author)
- Karolinska Institutet
-
Vandamme, Niels (author)
-
- Sorini, Chiara (author)
- Karolinska Institutet
-
Grundeken, Marijke Elise (author)
-
- Rolandsdotter, Helena (author)
- Karolinska Institutet
-
- Rassidakis, George (author)
- Karolinska Institutet
-
Villablanca, Eduardo J. (author)
-
Ideström, Maja (author)
-
Eulitz, Stefan (author)
-
- Arnell, Henrik (author)
- Karolinska Institutet
-
Mjösberg, Jenny (author)
-
Henter, Jan-Inge (author)
-
- Svensson, Mattias (author)
- Karolinska Institutet
-
show less...
-
(creator_code:org_t)
- Springer Nature, 2024
- 2024
- English.
-
In: Nature Communications. - : Springer Nature. - 2041-1723. ; 15:1
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
http://kipublication...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Stromal cells support epithelial cell and immune cell homeostasis and play an important role in inflammatory bowel disease (IBD) pathogenesis. Here, we quantify the stromal response to inflammation in pediatric IBD and reveal subset-specific inflammatory responses across colon segments and intestinal layers. Using data from a murine dynamic gut injury model and human ex vivo transcriptomic, protein and spatial analyses, we report that PDGFRA+CD142−/low fibroblasts and monocytes/macrophages co-localize in the intestine. In primary human fibroblast-monocyte co-cultures, intestinal PDGFRA+CD142−/low fibroblasts foster monocyte transition to CCR2+CD206+ macrophages through granulocyte-macrophage colony-stimulating factor (GM-CSF). Monocyte-derived CCR2+CD206+ cells from co-cultures have a phenotype similar to intestinal CCR2+CD206+ macrophages from newly diagnosed pediatric IBD patients, with high levels of PD-L1 and low levels of GM-CSF receptor. The study describes subset-specific changes in stromal responses to inflammation and suggests that the intestinal stroma guides intestinal macrophage differentiation.
Subject headings
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Kvedaraite, Egle
-
Lourda, Magda
-
Mouratidou, Nata ...
-
Düking, Tim
-
Padhi, Avinash
-
Moll, Kirsten
-
show more...
-
Czarnewski, Paul ...
-
Sinha, Indranil
-
Xagoraris, Ioann ...
-
Kokkinou, Efthym ...
-
Damdimopoulos, A ...
-
Weigel, Whitney
-
Hartwig, Olga
-
Santos, Telma E.
-
Soini, Tea
-
Van Acker, Aline
-
Rahkonen, Nelly
-
Flodström Tullbe ...
-
Ringqvist, Emma
-
Buggert, Marcus
-
Jorns, Carl
-
Lindforss, Ulrik
-
Nordenvall, Caro ...
-
Stamper, Christo ...
-
Jess, David Unne ...
-
Akber, Mira
-
Nadisauskaite, R ...
-
Jansson, Jessica
-
Vandamme, Niels
-
Sorini, Chiara
-
Grundeken, Marij ...
-
Rolandsdotter, H ...
-
Rassidakis, Geor ...
-
Villablanca, Edu ...
-
Ideström, Maja
-
Eulitz, Stefan
-
Arnell, Henrik
-
Mjösberg, Jenny
-
Henter, Jan-Inge
-
Svensson, Mattia ...
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Immunology
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Cell Biology
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Gastroenterology ...
- Articles in the publication
-
Nature Communica ...
- By the university
-
Stockholm University
-
Royal Institute of Technology
-
Karolinska Institutet