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Sex-Specific Associ...
Sex-Specific Associations between Prenatal Exposure to Di(2-ethylhexyl) Phthalate, Epigenetic Age Acceleration, and Susceptibility to Early Childhood Upper Respiratory Infections
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Merrill, Sarah M. (author)
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Letourneau, Nicole (author)
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Giesbrecht, Gerald F. (author)
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Edwards, Karlie (author)
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MacIsaac, Julia L. (author)
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- Martin, Jonathan W., 1975- (author)
- Stockholms universitet,Institutionen för miljövetenskap,Science for Life Laboratory (SciLifeLab)
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MacDonald, Amy M. (author)
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Kinniburgh, David W. (author)
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Kobor, Michael S. (author)
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Dewey, Deborah (author)
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England-Mason, Gillian (author)
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Epigenomes. - 2075-4655. ; 8:1
- Related links:
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Subject headings
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- Di(2-ethylhexyl) phthalate (DEHP) is a common plasticizer that can affect immune system development and susceptibility to infection. Aging processes (measured as epigenetic age acceleration (EAA)) may mediate the immune-related effects of prenatal exposure to DEHP. This study’s objective was to examine associations between prenatal DEHP exposure, EAA at three months of age, and the number of upper respiratory infections (URIs) from 12 to 18 months of age using a sample of 69 maternal–child pairs from a Canadian pregnancy cohort. Blood DNA methylation data were generated using the Infinium HumanMethylation450 BeadChip; EAA was estimated using Horvath’s pan-tissue clock. Robust regressions examined overall and sex-specific associations. Higher prenatal DEHP exposure (B = 6.52, 95% CI = 1.22, 11.81) and increased EAA (B = 2.98, 95% CI = 1.64, 4.32) independently predicted more URIs. In sex-specific analyses, some similar effects were noted for boys, and EAA mediated the association between prenatal DEHP exposure and URIs. In girls, higher prenatal DEHP exposure was associated with decreased EAA, and no mediation was noted. Higher prenatal DEHP exposure may be associated with increased susceptibility to early childhood URIs, particularly in boys, and aging biomarkers such as EAA may be a biological mechanism. Larger cohort studies examining the potential developmental immunotoxicity of phthalates are needed.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Keyword
- phthalates
- DNA methylation
- epigenetic clock
- common cold
- immunotoxicity
Publication and Content Type
- ref (subject category)
- art (subject category)
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Epigenomes
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Merrill, Sarah M ...
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Letourneau, Nico ...
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Giesbrecht, Gera ...
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Edwards, Karlie
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MacIsaac, Julia ...
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Martin, Jonathan ...
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show more...
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MacDonald, Amy M ...
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Kinniburgh, Davi ...
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Kobor, Michael S ...
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Dewey, Deborah
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England-Mason, G ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
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Epigenomes
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Stockholm University