Search: onr:"swepub:oai:DiVA.org:su-228698" >
Cardiometabolic dis...
Cardiometabolic disease, cognitive decline, and brain structure in middle and older age
-
- Dove, Abigail (author)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
-
- Guo, Jie (author)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
-
Wang, Jiao (author)
-
show more...
-
- Vetrano, Davide Liborio (author)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Stockholm Gerontology Research Center, Sweden
-
- Sakakibara, Sakura (author)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
-
- Laukka, Erika J. (author)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Stockholm Gerontology Research Center, Sweden
-
Bennett, David A. (author)
-
- Xu, Weili (author)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Tianjin Medical University, China
-
show less...
-
(creator_code:org_t)
- 2024
- 2024
- English.
-
In: Alzheimer's and Dementia. - 2352-8729. ; 16:2
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- INTRODUCTION: The presence of multiple cardiometabolic diseases (CMDs) has been linked to increased dementia risk, but the combined influence of CMDs on cognition and brain structure across the life course is unclear.METHODS: In the UK Biobank, 46,562 dementia-free participants completed a cognitive test battery at baseline and a follow-up visit 9 years later, at which point 39,306 also underwent brain magnetic resonance imaging. CMDs (diabetes, heart disease, and stroke) were ascertained from medical records. Data were analyzed using age-stratified (middle age [< 60] versus older [≥ 60]) mixed-effects models and linear regression.RESULTS: A higher number of CMDs was associated with significantly steeper global cognitive decline in older (β = –0.008; 95% confidence interval: −0.012, −0.005) but not middle age. Additionally, the presence of multiple CMDs was related to smaller total brain volume, gray matter volume, white matter volume, and hippocampal volume and larger white matter hyperintensity volume, even in middle age.DISCUSSION: CMDs are associated with cognitive decline in older age and poorer brain structural health beginning already in middle age.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- brain magnetic resonance imaging
- cardiometabolic disease
- cognitive decline
- cognitive domains
- population-based follow-up study
- UK Biobank
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database