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Capturing tumor com...
Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery
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Stock, Kristin (author)
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Estrada, Marta F. (author)
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Vidic, Suzana (author)
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Gjerde, Kjersti (author)
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Rudisch, Albin (author)
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Santo, Vítor E. (author)
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Barbier, Michaël (author)
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Blom, Sami (author)
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Arundkar, Sharath C. (author)
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Selvam, Irwin (author)
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Osswald, Annika (author)
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Stein, Yan (author)
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Gruenewald, Sylvia (author)
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Brito, Catarina (author)
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van Weerden, Wytske (author)
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Rotter, Varda (author)
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Boghaert, Erwin (author)
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Oren, Moshe (author)
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Sommergruber, Wolfgang (author)
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Chong, Yolanda (author)
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de Hoogt, Ronald (author)
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Graeser, Ralph (author)
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- 2016-07-01
- 2016
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6:1
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Two-dimensional (2D) cell cultures growing on plastic do not recapitulate the three dimensional (3D) architecture and complexity of human tumors. More representative models are required for drug discovery and validation. Here, 2D culture and 3D mono- and stromal co-culture models of increasing complexity have been established and cross-comparisons made using three standard cell carcinoma lines: MCF7, LNCaP, NCI-H1437. Fluorescence-based growth curves, 3D image analysis, immunohistochemistry and treatment responses showed that end points differed according to cell type, stromal co-culture and culture format. The adaptable methodologies described here should guide the choice of appropriate simple and complex in vitro models.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Stock, Kristin
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Estrada, Marta F ...
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Vidic, Suzana
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Gjerde, Kjersti
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Rudisch, Albin
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Santo, Vítor E.
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show more...
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Barbier, Michaël
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Blom, Sami
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Arundkar, Sharat ...
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Selvam, Irwin
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Osswald, Annika
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Stein, Yan
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Gruenewald, Sylv ...
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Brito, Catarina
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van Weerden, Wyt ...
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Rotter, Varda
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Boghaert, Erwin
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Oren, Moshe
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Sommergruber, Wo ...
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Chong, Yolanda
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de Hoogt, Ronald
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Graeser, Ralph
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Scientific Repor ...
- By the university
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Stockholm University