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Longitudinal study ...
Longitudinal study of Alzheimer's disease biomarkers, allostatic load, and cognition among memory clinic patients
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- Adedeji, Dickson O. (author)
- Psychiatric Clinic, Vrinnevi Hospital, Norrköping, Sweden,Region Östergötland, Psykiatriska kliniken i Norrköping,Karolinska Inst, Sweden
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- Holleman, Jasper (author)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Juster, Robert-Paul (author)
- Ageing Epidemiology Research Unit (AGE), School of Public Health, Faculty of Medicine, Imperial College London, United Kingdom,Univ Montreal, Canada
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- Udeh-Momoh, Chinedu T. (author)
- Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden; Imperial Coll London, England
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- Kåreholt, Ingemar, 1960- (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Jönköping University, Sweden,HHJ, Institutet för gerontologi,HHJ. ARN-J (Aging Research Network - Jönköping),Karolinska Inst, Sweden; Jonkoping Univ, Sweden; Stockholm Univ, Sweden
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- Hagman, Göran (author)
- Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Aspö, Malin (author)
- Karolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Adagunodo, Sofia (author)
- Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden,Memory Clin Zentralschweiz, Switzerland
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- Håkansson, Krister (author)
- Karolinska Institutet,Karolinska Inst, Sweden
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- Kivipelto, Miia (author)
- Karolinska Institutet,Karolinska Inst, Sweden; Imperial Coll London, England; Karolinska Univ Hosp, Sweden; Univ Eastern Finland, Finland
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- Solomon, Alina (author)
- Karolinska Institutet,Karolinska Inst, Sweden; Imperial Coll London, England; Karolinska Univ Hosp, Sweden; Univ Eastern Finland, Finland
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- Sindi, Shireen (author)
- Karolinska Institutet,Karolinska Inst, Sweden; Imperial Coll London, England; Care Sci & Soc NVS, Sweden
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(creator_code:org_t)
- Elsevier BV, 2023
- 2023
- English.
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In: Brain, Behavior, and Immunity - Health. - : Elsevier BV. - 2666-3546. ; 28
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- Background: Allostatic load (AL) is defined as the cumulative dysregulation of neuroendocrine, immunological, metabolic, and cardiovascular systems that increases the susceptibility to stress-related health problems. Several dementia and Alzheimer's disease (AD) risk factors have been identified, yet little is known about the role of AL and its associations with AD biomarkers (e.g., beta-amyloid (Aβ) or tau) and cognitive function among memory clinic patients. Hence, this study aims to assess the association between AL and AD biomarkers, cognitive performance, and cognitive decline after 3-years of follow-up.Methods: Data from 188 memory clinic patients were derived from the Cortisol and Stress in AD (Co-STAR) study in Sweden. Participants underwent baseline assessments including blood tests for AL measures (including cortisol, thyroid stimulating hormone, cobalamin, homocysteine, leukocytes, glycated hemoglobin, albumin, high-density and low-density lipoprotein cholesterol, triglycerides, and creatinine), cerebrospinal fluid (CSF) sampling for AD biomarkers and neuropsychological tests including five cognitive domains. Linear regressions were conducted, adjusting for age, sex, and education.Results: Higher AL was associated with lower CSF Aβ1-42 levels (β = −0.175, p = 0.025), reflecting higher brain levels of Aβ1-42. Stratified analyses suggested a significant association among women but not men, although the AL-sex interaction was not statistically significant. AL was not significantly associated with T-tau level (β = −0.030, p = 0.682) and P-tau level (β = 0.091, p = 0.980). There were no significant associations between AL and cognition or cognitive decline after 3 years.Conclusion: This study showed that higher AL was associated with increased brain amyloid accumulation. This suggests that AL may play a role in AD/dementia pathophysiology. Potential sex-related differences should be assessed in further larger studies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- Allostatic load
- Cognition
- AD biomarkers
- Chronic stress
- Memory clinic
Publication and Content Type
- ref (subject category)
- art (subject category)
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Adedeji, Dickson ...
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Holleman, Jasper
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Juster, Robert-P ...
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Udeh-Momoh, Chin ...
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Kåreholt, Ingema ...
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Hagman, Göran
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Aspö, Malin
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Adagunodo, Sofia
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Håkansson, Krist ...
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Kivipelto, Miia
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Solomon, Alina
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Sindi, Shireen
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- MEDICAL AND HEALTH SCIENCES
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and Neurology
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MEDICAL AND HEAL ...
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and Geriatrics
- Articles in the publication
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Brain, Behavior, ...
- By the university
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Stockholm University
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Jönköping University
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Karolinska Institutet
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Linköping University